{"id":"W2081452837","doi":"10.1038/labinvest.3700684","title":"Nuclear E-cadherin and VHL immunoreactivity are prognostic indicators of clear-cell renal cell carcinoma","year":2007,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Ontario Institute for Cancer Research; University of Toronto","funders":"Canadian Institutes of Health Research; Terry Fox Foundation; National Cancer Institute; Kidney Foundation of Canada","keywords":"Tissue microarray; Chromophobe cell; Renal cell carcinoma; Cadherin; Clear cell; Pathology; Biology; Immunostaining; Immunohistochemistry; Cancer research; Clear cell renal cell carcinoma; Medicine; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002070301,0.000117032,0.0001091757,0.00006143072,0.00006387624,0.00001101192,0.0000780328,0.0002121075,0.000005238661],"category_scores_gemma":[0.00003448351,0.000109452,0.00002935567,0.0002267996,0.0002197967,0.000009461293,0.00003884259,0.0001465276,0.000004302265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001956953,"about_ca_system_score_gemma":0.00009372405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003211892,"about_ca_topic_score_gemma":0.000009369306,"domain_scores_codex":[0.9992608,0.00005268172,0.0001913063,0.00022359,0.0001174727,0.0001541028],"domain_scores_gemma":[0.9994104,0.00001146351,0.0002243821,0.0001633095,0.00007628728,0.0001141922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000684143,0.00002892322,0.1025114,0.00006544397,0.00001130383,0.000003571901,0.0001281859,0.000009293645,0.8966527,0.00002852751,0.0002512377,0.0002410413],"study_design_scores_gemma":[0.0003404503,0.0002285588,0.1644076,0.0000207378,0.00002115826,0.000001702029,0.0002038112,0.000008877063,0.8322806,0.0000261135,0.002338897,0.0001214244],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998304,0.0007257072,0.00002090677,0.00003121095,0.00006568687,0.0001280826,0.00001806811,0.00001169556,0.0006946092],"genre_scores_gemma":[0.9994174,0.00007342449,0.0001884063,0.0001333054,0.00007137721,0.000003218223,0.0000367896,0.00001967302,0.00005642161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06437207,"threshold_uncertainty_score":0.4463324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003871463201602573,"score_gpt":0.1899005413405215,"score_spread":0.1860290781389189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}