{"id":"W2081452837","doi":"10.1038/labinvest.3700684","title":"Nuclear E-cadherin and VHL immunoreactivity are prognostic indicators of clear-cell renal cell carcinoma","year":2007,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Ontario Institute for Cancer Research; University of Toronto","funders":"Canadian Institutes of Health Research; Terry Fox Foundation; National Cancer Institute; Kidney Foundation of Canada","keywords":"Tissue microarray; Chromophobe cell; Renal cell carcinoma; Cadherin; Clear cell; Pathology; Biology; Immunostaining; Immunohistochemistry; Cancer research; Clear cell renal cell carcinoma; Medicine; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000707222,0.0003029786,0.0003125568,0.001425795,0.0002886246,0.0007000994,0.0003532025,0.000367389,0.0009898565],"category_scores_gemma":[0.002978806,0.0002154139,0.0001598237,0.0008985337,0.0005077963,0.0006745887,0.0002461692,0.0004780678,0.0002519495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002847945,"about_ca_system_score_gemma":0.0003587787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001429872,"about_ca_topic_score_gemma":0.001413691,"domain_scores_codex":[0.9997551,0.00006621609,0.00003365125,0.00003058137,0.00007066259,0.00004382058],"domain_scores_gemma":[0.9984512,0.0006052058,0.0003308032,0.00008929042,0.000278231,0.0002451837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000505709,0.00003838804,0.9867167,0.00002009901,0.00002719499,0.0002599887,0.00006754089,0.00009945512,0.005957198,0.00005494309,0.0001226567,0.006130082],"study_design_scores_gemma":[0.00001369856,0.0001314546,0.9923459,0.00000530199,0.00005885603,0.00124581,0.0002136432,0.0009664127,0.004384565,0.0001592213,0.000466943,0.000008173762],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972212,0.001144969,0.0003629751,0.00008701351,0.00001050375,0.000003927918,0.0001065733,0.00001724052,0.001045644],"genre_scores_gemma":[0.9993875,0.0002008752,0.0001332394,0.00001001085,0.00001890149,0.000002389597,0.00007696087,0.000001846659,0.0001682011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001429872,"threshold_uncertainty_score":0.003740191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003871463201602573,"score_gpt":0.1899005413405215,"score_spread":0.1860290781389189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}