{"id":"W2081460055","doi":"10.1016/j.ejphar.2012.07.012","title":"H-89 decreases the gain of excitation–contraction coupling and attenuates calcium sparks in the absence of beta-adrenergic stimulation","year":2012,"lang":"en","type":"article","venue":"European Journal of Pharmacology","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Internal medicine; IBMX; Forskolin; Endocrinology; Endoplasmic reticulum; Adenylyl cyclase; Calcium; Myocyte; Contraction (grammar); Stimulation; Phosphodiesterase; Chemistry; Biophysics; Biology; Enzyme; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00139745,0.00006685712,0.0002164004,0.0000816769,0.00004156428,0.000002346938,0.00005908602,0.00001937895,0.00003459024],"category_scores_gemma":[0.0001087378,0.00003819418,0.00007390725,0.0001005201,0.0001411414,0.0000875301,0.00001241856,0.0002477765,0.000001560371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001237539,"about_ca_system_score_gemma":0.00003124502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004858253,"about_ca_topic_score_gemma":5.231563e-7,"domain_scores_codex":[0.9988429,0.0005064427,0.0003694905,0.0000529952,0.0001054896,0.0001226937],"domain_scores_gemma":[0.9987455,0.0006419392,0.0003986371,0.00005442546,0.0001235896,0.00003590289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001089824,0.0001952426,0.02408072,0.00003899503,0.0002126233,0.0001455891,0.001559545,0.01218115,0.9572971,0.0002077301,0.0008172742,0.0021742],"study_design_scores_gemma":[0.002173963,0.0005807955,0.9499573,0.00005780629,0.0004360964,0.001024493,0.0004620712,0.002041739,0.0428482,0.00005220405,0.0003031372,0.0000621904],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961348,0.002191638,0.0003474749,0.0008127068,0.0002314695,0.0001045176,0.000001132873,0.000001802655,0.000174514],"genre_scores_gemma":[0.9987642,0.0002461127,0.00007652368,0.0003426065,0.0005522753,8.880457e-7,0.000002194053,0.000006816913,0.000008396573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9258766,"threshold_uncertainty_score":0.1557513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03155629884880107,"score_gpt":0.3234011784773236,"score_spread":0.2918448796285225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}