{"id":"W2081484991","doi":"10.1186/1742-4690-11-s1-o19","title":"Host restriction factor SAMHD1 limits human T-cell leukemia virus (HTLV-1) infection of primary monocytes via the innate immune sensor STING","year":2014,"lang":"en","type":"article","venue":"Retrovirology","topic":"T-cell and Retrovirus Studies","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"SAMHD1; Myeloid leukemia; Biology; Reverse transcriptase; IRF3; Virology; Innate immune system; Transcription factor; Apoptosis; RNA interference; Immune system; Molecular biology; Immunology; Gene; Genetics; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001115266,0.0001842546,0.0001834276,0.00009602876,0.0001365467,0.0002633636,0.00008272286,0.0001338297,0.0007727598],"category_scores_gemma":[0.00008783213,0.00007956292,0.0001719718,0.00006775015,0.0001408836,0.00009360896,0.0001467493,0.0003665522,0.0002301031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000232068,"about_ca_system_score_gemma":0.0002216039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005452064,"about_ca_topic_score_gemma":0.0009999679,"domain_scores_codex":[0.9998928,0.00001669526,0.000008747677,0.00002353138,0.0000226996,0.00003560871],"domain_scores_gemma":[0.9999509,0.00001040081,0.00001392296,0.000006407082,0.000007056493,0.00001129702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008892537,0.000009315616,0.0002161456,0.00002309675,0.000002074007,0.00001818285,0.0000141262,0.00003726669,0.9986305,0.00006558359,0.00002318206,0.0008716814],"study_design_scores_gemma":[0.000005916371,0.0001474673,0.002654375,0.000004071117,0.000008287465,0.00007324073,0.00001792192,0.000543959,0.9952214,0.0000195712,0.001301957,0.000001725928],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995139,0.00178088,0.001876537,0.00006011883,0.00001926319,0.00001341292,0.0001897479,0.00005351135,0.0008674996],"genre_scores_gemma":[0.9967032,0.0005674406,0.00135305,0.00003025125,0.000005577573,0.00001389423,0.0001830646,0.000005779727,0.001137775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007727598,"threshold_uncertainty_score":0.002585173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01599111065088827,"score_gpt":0.2240581429064046,"score_spread":0.2080670322555163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}