{"id":"W2081485057","doi":"10.1016/j.nbd.2014.08.006","title":"Selective loss of bi-directional synaptic plasticity in the direct and indirect striatal output pathways accompanies generation of parkinsonism and l-DOPA induced dyskinesia in mouse models","year":2014,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":83,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Drug Abuse; Natural Sciences and Engineering Research Council of Canada","keywords":"Long-term potentiation; Parkinsonism; Neuroscience; Synaptic plasticity; Direct pathway of movement; Excitatory postsynaptic potential; Indirect pathway of movement; Stimulation; Dyskinesia; Biology; Medicine; Dopamine; Striatum; Parkinson's disease; Internal medicine; Inhibitory postsynaptic potential","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000181112,0.0007791637,0.0004049292,0.0009978518,0.0003054142,0.0005297006,0.0003698136,0.0007344265,0.001914365],"category_scores_gemma":[0.0001610787,0.0004502334,0.0004985646,0.0002656658,0.0006160021,0.0004284645,0.0004715419,0.00168946,0.0005220056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005163151,"about_ca_system_score_gemma":0.0003573449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001370565,"about_ca_topic_score_gemma":0.004435822,"domain_scores_codex":[0.9996867,0.00002650738,0.00003649912,0.00009174732,0.00009116183,0.00006742281],"domain_scores_gemma":[0.9995307,0.00002855347,0.0001999506,0.00003533416,0.00003447916,0.0001711407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001326494,0.00002340106,0.0002511598,0.00001804824,0.000008709947,0.00009127847,0.000009826087,0.00004882272,0.9986907,0.0001231349,0.00003165381,0.0005707539],"study_design_scores_gemma":[0.00003772472,0.0003618568,0.01731299,0.00001823824,0.00007190615,0.001187675,0.00006360309,0.001968914,0.9776431,0.000243283,0.001077809,0.00001280247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915192,0.0007897675,0.004564769,0.0001844764,0.00004428819,0.00004267163,0.001158389,0.000214137,0.001482372],"genre_scores_gemma":[0.9898697,0.0005444376,0.003232206,0.00008366868,0.00001060379,0.00007509316,0.0005835326,0.0001032631,0.005497633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001914365,"threshold_uncertainty_score":0.006404161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07973693703578431,"score_gpt":0.2909581770169969,"score_spread":0.2112212399812126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}