{"id":"W2081485322","doi":"10.1039/c4md00209a","title":"Synthesis of 1-O-acetylbritannilactone analogues from Inula britannica and in vitro evaluation of their anticancer potential","year":2014,"lang":"en","type":"article","venue":"MedChemComm","topic":"Sesquiterpenes and Asteraceae Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nutrasource","funders":"National Natural Science Foundation of China","keywords":"HeLa; In vitro; Ring (chemistry); Chemistry; Stereochemistry; Apoptosis; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000867396,0.0004132488,0.0001961078,0.0003489797,0.0001627589,0.0001600202,0.0002705387,0.0001833143,0.003188066],"category_scores_gemma":[0.00008529191,0.0001125631,0.0002255731,0.0002990795,0.0001337912,0.0002052111,0.0001305712,0.000371404,0.0006988351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002135867,"about_ca_system_score_gemma":0.0002174791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008447708,"about_ca_topic_score_gemma":0.002411083,"domain_scores_codex":[0.9999622,0.000007016103,0.000004660677,0.00000685217,0.000007408482,0.00001192811],"domain_scores_gemma":[0.9999557,0.000004130814,0.00001051525,0.000006601185,0.000008221593,0.00001494693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000268957,0.0001137233,0.0001288743,0.0002538907,0.00001194697,0.0001881019,0.00003714363,0.0005945724,0.9910705,0.0003065592,0.0001346596,0.00689106],"study_design_scores_gemma":[0.0001048999,0.002419113,0.004703071,0.00003551505,0.00006943119,0.0003248523,0.0000608937,0.0004997799,0.9736543,0.0001742955,0.01791882,0.00003498686],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.963585,0.008021102,0.005528708,0.0002782952,0.0001253137,0.0003407468,0.0025931,0.0001845801,0.01934311],"genre_scores_gemma":[0.9855592,0.003560744,0.003758542,0.0001035092,0.00002264767,0.0000986936,0.001301231,0.00001874064,0.005576627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003188066,"threshold_uncertainty_score":0.01066518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01282737396250419,"score_gpt":0.2638662128028463,"score_spread":0.2510388388403421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}