{"id":"W2081525522","doi":"10.1021/bi020100c","title":"Effects of T142 Phosphorylation and Mutation R145G on the Interaction of the Inhibitory Region of Human Cardiac Troponin I with the C-Domain of Human Cardiac Troponin C","year":2002,"lang":"en","type":"article","venue":"Biochemistry","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"University of Illinois at Chicago; University of Kent","keywords":"Troponin I; Phosphorylation; Troponin complex; Myofilament; Missense mutation; Actin; Cardiac muscle; Chemistry; Mutation; Tropomyosin; Biophysics; Molecular biology; Biochemistry; Biology; Internal medicine; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002875279,0.0005951398,0.0003001284,0.0001334948,0.0002373352,0.0002329281,0.0003493096,0.0007834825,0.001719401],"category_scores_gemma":[0.0004000094,0.00024337,0.0005228853,0.0001415143,0.0003689016,0.0001892128,0.0002315058,0.0004847675,0.0004315348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002452701,"about_ca_system_score_gemma":0.000251244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001802452,"about_ca_topic_score_gemma":0.001258717,"domain_scores_codex":[0.9997103,0.00008694566,0.00003944023,0.00006561337,0.00004570516,0.00005195516],"domain_scores_gemma":[0.9997534,0.00007922785,0.00006194468,0.00002110748,0.00001411816,0.00007016288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002787582,0.0007631065,0.001492276,0.00008332911,0.00009158583,0.002125974,0.0001074659,0.00100149,0.9880114,0.0003440542,0.0003087425,0.002882921],"study_design_scores_gemma":[0.0007197128,0.008503905,0.02453957,0.00004487437,0.000251951,0.004918316,0.0001736307,0.01161975,0.9454094,0.0002198098,0.003519494,0.00007961355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988372,0.000291811,0.0002087495,0.00005791458,0.00004286262,0.00002328521,0.00009250249,0.00001441156,0.0004312386],"genre_scores_gemma":[0.9987395,0.0001781954,0.0003161836,0.0001023411,0.00001550525,0.00001599478,0.000148088,0.00001623036,0.0004678908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001802452,"threshold_uncertainty_score":0.005752027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009043123430842043,"score_gpt":0.2269959247920277,"score_spread":0.2179528013611857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}