{"id":"W2081536974","doi":"10.1021/bi800355t","title":"The bZIP Targets Overlapping DNA Subsites within a Half-Site, Resulting in Increased Binding Affinities","year":2008,"lang":"en","type":"article","venue":"Biochemistry","topic":"Diffusion and Search Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences","keywords":"bZIP domain; Affinities; Binding site; Leucine zipper; DNA; Zipper; Chemistry; DNA footprinting; Footprinting; Binding affinities; Stereochemistry; Biochemistry; DNA-binding protein; Peptide sequence; Transcription factor; Base sequence; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002219253,0.0004453264,0.0005115199,0.0002374342,0.0002108674,0.0003268537,0.0005489424,0.0003721389,0.001827205],"category_scores_gemma":[0.0003755158,0.0003029682,0.0002404631,0.0001524357,0.0004407865,0.0004224322,0.0004662139,0.000573307,0.0006022144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004808838,"about_ca_system_score_gemma":0.0001562578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005708171,"about_ca_topic_score_gemma":0.0007948678,"domain_scores_codex":[0.9997543,0.00002671772,0.00001335329,0.00009863083,0.00006596498,0.0000411835],"domain_scores_gemma":[0.9997889,0.00006127495,0.00005315563,0.00002181174,0.00002680557,0.00004805276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003337612,0.000005418349,0.000272924,0.00002789256,0.000004466833,0.0000125307,0.000009774938,0.00009396867,0.998514,0.000120846,0.000009639346,0.0008952033],"study_design_scores_gemma":[0.000008680197,0.00006801566,0.004094998,0.000003625636,0.00001175159,0.0002202819,0.00002338558,0.002433885,0.9916884,0.000140518,0.001299676,0.000006863084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808178,0.001508139,0.01591165,0.0001002324,0.00002041171,0.00002444852,0.00009059133,0.0001112469,0.001415506],"genre_scores_gemma":[0.9875064,0.0004550181,0.0104144,0.00004889946,0.000006766378,0.00003965744,0.0002040706,0.00002406919,0.001300779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001827205,"threshold_uncertainty_score":0.006112635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01360694704373278,"score_gpt":0.2357349977174197,"score_spread":0.222128050673687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}