{"id":"W2081563943","doi":"10.1016/j.bpj.2010.12.1267","title":"Single Molecule Studies Reveal Sliding Dynamics of Hcv NS5B in Complex with RNA","year":2011,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"RNA; NS5B; RNA polymerase; Biophysics; Nucleic acid; Chemistry; Förster resonance energy transfer; Polymerase; Binding site; Single-molecule FRET; DNA; Biochemistry; Biology; Fluorescence; Gene; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001964074,0.0002034906,0.000430584,0.0001972204,0.0005046788,0.0005117223,0.0004392409,0.0003724337,0.00239997],"category_scores_gemma":[0.0004044132,0.0002906889,0.0002446836,0.0002225129,0.0004364026,0.0005008219,0.0002529047,0.0008696718,0.0002609185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007556468,"about_ca_system_score_gemma":0.0002028258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002585681,"about_ca_topic_score_gemma":0.002948,"domain_scores_codex":[0.9998492,0.00001131337,0.000007133053,0.00004138009,0.00005100985,0.00003995578],"domain_scores_gemma":[0.9997153,0.0001123324,0.0000513188,0.00003032094,0.0000250463,0.00006571922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003163264,0.00009842061,0.002883858,0.00008038789,0.00006422438,0.0002010166,0.000283877,0.001123409,0.9910727,0.0007477484,0.0002879871,0.002840019],"study_design_scores_gemma":[0.00007060196,0.0004271236,0.06351588,0.00002242555,0.00008043398,0.0004712554,0.0005363884,0.09695,0.8344373,0.0005774851,0.002821439,0.00008960625],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982179,0.0002496326,0.0008232858,0.00007882949,0.00001096382,0.000004180934,0.00006916892,0.00001755803,0.0005284186],"genre_scores_gemma":[0.9987312,0.0001364721,0.0004835449,0.00003021542,0.000007386255,0.000007058205,0.0001238463,0.0000117756,0.0004684957],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002585681,"threshold_uncertainty_score":0.008028746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05359032326661681,"score_gpt":0.2993545085248019,"score_spread":0.2457641852581851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}