{"id":"W2081575623","doi":"10.1371/journal.pone.0090024","title":"Regulation of hERG and hEAG Channels by Src and by SHP-1 Tyrosine Phosphatase via an ITIM Region in the Cyclic Nucleotide Binding Domain","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; National Science Foundation","keywords":"hERG; Protein tyrosine phosphatase; SH2 domain; Proto-oncogene tyrosine-protein kinase Src; Receptor tyrosine kinase; Tyrosine phosphorylation; Phosphorylation; Tyrosine; Tyrosine kinase; Phosphatase; Cell biology; Biology; Chemistry; Biochemistry; Signal transduction; Potassium channel; Biophysics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001475078,0.0002155327,0.0001455774,0.0000931971,0.0001013859,0.0002265899,0.0001789868,0.0001841201,0.000979431],"category_scores_gemma":[0.0001405268,0.00007533616,0.0002089927,0.00007778494,0.0002541685,0.0001819435,0.000190363,0.0003353549,0.000226227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002733847,"about_ca_system_score_gemma":0.0001723936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003929255,"about_ca_topic_score_gemma":0.0005079008,"domain_scores_codex":[0.9998696,0.00001847883,0.000006225675,0.0000206988,0.0000316758,0.00005326125],"domain_scores_gemma":[0.9999408,0.000008845049,0.00001874183,0.000005421001,0.000005819603,0.0000203661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002817553,0.00004385416,0.0004313199,0.0000527589,0.000006488698,0.0001251671,0.00002343503,0.0001562833,0.9952992,0.0004365961,0.0001254045,0.003017528],"study_design_scores_gemma":[0.000168248,0.0005427797,0.03262378,0.00000990583,0.0000321447,0.0007623649,0.00008502763,0.004248253,0.9547961,0.0003852392,0.006334178,0.00001203884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918834,0.003601651,0.001446212,0.0001704739,0.00003969726,0.00001951123,0.0001397547,0.00007559361,0.002623705],"genre_scores_gemma":[0.9970151,0.001023615,0.0005417914,0.00007261142,0.00001209782,0.00002775293,0.0001768395,0.000009102514,0.001121189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000979431,"threshold_uncertainty_score":0.003276527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01643374619333579,"score_gpt":0.2119834598061132,"score_spread":0.1955497136127774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}