{"id":"W2081658993","doi":"10.1016/j.bmcl.2010.09.087","title":"Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Cognitive impairment; Cognition; Pharmacology; Neuroscience; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002698417,0.0006160637,0.0008647759,0.0003998939,0.0002111748,0.0005116276,0.0006462674,0.0006420378,0.001303803],"category_scores_gemma":[0.00018712,0.0003178656,0.0006685175,0.0001803347,0.0002481404,0.0003016838,0.0002445835,0.001086026,0.000553121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004878687,"about_ca_system_score_gemma":0.0005632191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001152854,"about_ca_topic_score_gemma":0.003331768,"domain_scores_codex":[0.9999194,0.00001163633,0.000008243169,0.00001279689,0.00001486835,0.00003306522],"domain_scores_gemma":[0.9999524,0.000006123236,0.000008669366,0.000003811283,0.000008631755,0.00002040189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004745891,0.001283719,0.001690078,0.0006168262,0.0002621585,0.003019226,0.00009696239,0.001015239,0.8513583,0.002631055,0.004569989,0.1287106],"study_design_scores_gemma":[0.01929226,0.03807296,0.03804002,0.0002224418,0.001794045,0.01674075,0.0001515244,0.0105323,0.7990482,0.001435534,0.07446361,0.0002063103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9566357,0.01966078,0.006767659,0.002811739,0.0004079346,0.0004890857,0.001367125,0.0004718232,0.01138818],"genre_scores_gemma":[0.9796463,0.009080661,0.004431447,0.00103841,0.0001316702,0.0001193059,0.001116275,0.00002329023,0.004412692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001303803,"threshold_uncertainty_score":0.004361629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00703732679574486,"score_gpt":0.2385464185508802,"score_spread":0.2315090917551353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}