{"id":"W2081673104","doi":"10.1007/s10549-011-1375-8","title":"Biomarkers of PARP inhibitor sensitivity","year":2011,"lang":"en","type":"letter","venue":"Breast Cancer Research and Treatment","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Breast cancer; Sensitivity (control systems); Medicine; PARP inhibitor; Biomarker; Oncology; Internal medicine; Poly ADP ribose polymerase; Biology; Cancer; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002087184,0.0009834119,0.001636105,0.0009875365,0.001334117,0.003111457,0.0007208105,0.01418837,0.008166176],"category_scores_gemma":[0.01443983,0.0003603297,0.0008693297,0.0007225454,0.001483706,0.001617518,0.001180168,0.01316401,0.005268398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002574418,"about_ca_system_score_gemma":0.001200148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009415676,"about_ca_topic_score_gemma":0.001891303,"domain_scores_codex":[0.9978701,0.0007623377,0.0002096775,0.0002459837,0.0005687576,0.0003430978],"domain_scores_gemma":[0.9958014,0.002244897,0.0004122214,0.0001952054,0.0008530712,0.0004931358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003849896,0.00009961534,0.009544199,0.0002379396,0.00004672177,0.005536284,0.0001342835,0.0002288898,0.00178053,0.004449165,0.9060209,0.07153653],"study_design_scores_gemma":[0.0003023074,0.0005412555,0.01468559,0.001037494,0.0001249534,0.01424529,0.0006508311,0.001482665,0.002577214,0.02310647,0.9411328,0.0001131222],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.002874081,0.008634537,0.0007599789,0.9367204,0.02972727,0.00006432528,0.0004191916,0.00008971177,0.02071046],"genre_scores_gemma":[0.06173293,0.01075859,0.002107371,0.7520055,0.1203332,0.0004832554,0.0005408293,0.00006353668,0.0519747],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01418837,"threshold_uncertainty_score":0.02731854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1079439136208275,"score_gpt":0.3851781254831829,"score_spread":0.2772342118623554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}