{"id":"W2081683698","doi":"10.1111/j.1582-4934.2009.00904.x","title":"TNF‐α‐mediated signal transduction pathway is a major determinant of apoptosis in dilated cardiomyopathy","year":2009,"lang":"en","type":"article","venue":"Journal of Cellular and Molecular Medicine","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"Canadian Institutes of Health Research","keywords":"Apoptosis; Internal medicine; Dilated cardiomyopathy; Endocrinology; Signal transduction; Protein kinase C; p38 mitogen-activated protein kinases; MAPK/ERK pathway; Ventricle; Cardiomyopathy; Biology; Tumor necrosis factor alpha; Protein kinase A; Phosphorylation; Medicine; Heart failure; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001509024,0.0002360273,0.000204556,0.0002177293,0.0001183905,0.0001410418,0.00008779729,0.0001914386,0.000538003],"category_scores_gemma":[0.0001065066,0.0001492219,0.0001138088,0.00007984811,0.0002318648,0.0001662322,0.0001162023,0.0002506844,0.0001948133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001787044,"about_ca_system_score_gemma":0.00007862488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001162175,"about_ca_topic_score_gemma":0.0001458017,"domain_scores_codex":[0.9999261,0.00001752819,0.000009229859,0.00001697174,0.00001329627,0.00001690619],"domain_scores_gemma":[0.9998566,0.00001345399,0.00005818533,0.00001587785,0.00001567806,0.0000401185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002763231,0.00003172972,0.003068618,0.00002158299,0.000004207815,0.0001974041,0.00001235585,0.00002656166,0.995611,0.00003550975,0.00001096891,0.0007038778],"study_design_scores_gemma":[0.0001650106,0.003064979,0.3584104,0.00003962426,0.00009090208,0.005476224,0.0001626295,0.001844693,0.6285865,0.0004468737,0.001699406,0.00001281088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985803,0.0007139965,0.0003571508,0.00002529761,0.000006111115,0.000005608034,0.00003387749,0.00001067497,0.0002670334],"genre_scores_gemma":[0.9987657,0.0004820068,0.0002289269,0.00001261825,0.00000605375,0.000007153778,0.00008276567,0.000002035334,0.0004126339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000538003,"threshold_uncertainty_score":0.001799762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005104784242544054,"score_gpt":0.2132524247528166,"score_spread":0.2081476405102726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}