{"id":"W2081709918","doi":"10.1021/jm800112s","title":"1-[(Imidazolidin-2-yl)imino]indazole. Highly α<sub>2</sub>/I<sub>1</sub> Selective Agonist: Synthesis, X-ray Structure, and Biological Activity","year":2008,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Imidazoline receptor; Chemistry; Agonist; Selectivity; Antagonist; Indazole; Moiety; Stereochemistry; Chemical synthesis; Imidazolidine; Ligand (biochemistry); Pharmacology; Receptor; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004671282,0.000464275,0.0007877661,0.00008182894,0.000291456,0.0000227731,0.0003605417,0.0006731918,0.00002797144],"category_scores_gemma":[0.0005202792,0.0003600064,0.0002593138,0.0001535281,0.000621761,0.00002044764,0.0001727302,0.0009676813,0.000002892744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007817861,"about_ca_system_score_gemma":0.0004570171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002832585,"about_ca_topic_score_gemma":0.000002068021,"domain_scores_codex":[0.9976059,0.000175558,0.0006316219,0.0005560357,0.0004772785,0.0005535606],"domain_scores_gemma":[0.9979568,0.00016228,0.0006440804,0.0002799395,0.0004365403,0.0005204243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009875163,0.0002034191,0.001931465,0.00006826804,0.0002844742,0.0005024036,0.00004965391,0.00001428328,0.9854676,0.000002090554,0.005756613,0.004732239],"study_design_scores_gemma":[0.001510472,0.0005753372,0.01741328,0.00006734945,0.0002036379,0.005713256,0.00006386969,0.00002201273,0.972091,0.00005168705,0.001904544,0.0003836193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996185,0.002397513,0.000103294,0.0006195272,0.0003237178,0.0001249925,0.00005171916,0.00001571464,0.0001785138],"genre_scores_gemma":[0.9922029,0.005229743,0.0001462791,0.0006745711,0.00166168,0.000008380498,0.00002493952,0.00003924593,0.00001230738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01548181,"threshold_uncertainty_score":0.9998852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01613937076219844,"score_gpt":0.2431790825383362,"score_spread":0.2270397117761378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}