{"id":"W2081709918","doi":"10.1021/jm800112s","title":"1-[(Imidazolidin-2-yl)imino]indazole. Highly α<sub>2</sub>/I<sub>1</sub> Selective Agonist: Synthesis, X-ray Structure, and Biological Activity","year":2008,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Imidazoline receptor; Chemistry; Agonist; Selectivity; Antagonist; Indazole; Moiety; Stereochemistry; Chemical synthesis; Imidazolidine; Ligand (biochemistry); Pharmacology; Receptor; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005497497,0.0003066273,0.0002561461,0.00009693609,0.00009945528,0.0000953517,0.0002611946,0.0001558836,0.001431675],"category_scores_gemma":[0.0000642243,0.000108156,0.00007015284,0.0001757325,0.0001070158,0.0001127421,0.0001028395,0.0002672987,0.0007555144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002480515,"about_ca_system_score_gemma":0.0001636804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005694553,"about_ca_topic_score_gemma":0.002147797,"domain_scores_codex":[0.9999487,0.000006341489,0.000002958303,0.000008737811,0.00001464211,0.0000184932],"domain_scores_gemma":[0.9999692,0.000002533851,0.00001136525,0.000002022728,0.000008421439,0.00000640753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008852383,0.00002281275,0.0001374704,0.00008327616,0.000002989729,0.0000613089,0.000008671708,0.00007679562,0.9963565,0.00006358183,0.000124296,0.00297381],"study_design_scores_gemma":[0.0001233362,0.001834299,0.009494212,0.00001794359,0.00003719029,0.001022005,0.00002886049,0.0009216953,0.9693628,0.00004133305,0.01710271,0.00001367955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9612849,0.01323803,0.01197141,0.0002665228,0.0001109128,0.0001362727,0.0007363334,0.0004633273,0.01179225],"genre_scores_gemma":[0.9815269,0.004401567,0.006134829,0.0001155553,0.00003607441,0.00007136735,0.0009878156,0.00002033597,0.006705596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001431675,"threshold_uncertainty_score":0.004789412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01613937076219844,"score_gpt":0.2431790825383362,"score_spread":0.2270397117761378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}