{"id":"W2081744051","doi":"10.1038/mt.2011.21","title":"RNAi-based Therapeutics Targeting Survivin and PLK1 for Treatment of Bladder Cancer","year":2011,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Survivin; RNA interference; PLK1; Bladder cancer; Cancer research; Cancer; Medicine; Biology; Internal medicine; Cell cycle; Gene; Genetics; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001785476,0.0003126942,0.0004007933,0.0003621374,0.0001248657,0.0002970508,0.0002417301,0.0002851181,0.0005076385],"category_scores_gemma":[0.00009652553,0.0001548977,0.0002676382,0.0002351435,0.0001968505,0.0002707849,0.0002089821,0.0005305887,0.0001970281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005154742,"about_ca_system_score_gemma":0.0004453706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006687004,"about_ca_topic_score_gemma":0.001123432,"domain_scores_codex":[0.9999177,0.00001445127,0.000009322385,0.00001829926,0.00002506428,0.00001522354],"domain_scores_gemma":[0.9999694,0.000004249968,0.00001175119,0.000002275734,0.00000523358,0.000007025856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001041892,0.00005736197,0.0002106002,0.0002165909,0.00001236335,0.00006491625,0.00001968579,0.0003780267,0.9846726,0.0001995972,0.0001168743,0.01394713],"study_design_scores_gemma":[0.00004361809,0.0007459017,0.001744303,0.00001755974,0.00006329923,0.000441442,0.00001208883,0.001554684,0.9888867,0.00005780922,0.006420172,0.00001244624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8669527,0.09478448,0.0320063,0.0007802743,0.0001552139,0.0003028337,0.0005058025,0.0006308396,0.003881564],"genre_scores_gemma":[0.9536363,0.03062049,0.01201378,0.0001468102,0.00003660787,0.0001212822,0.0004708513,0.00003392857,0.0029199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006687004,"threshold_uncertainty_score":0.003740072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05700986241924001,"score_gpt":0.2890758528448251,"score_spread":0.2320659904255851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}