{"id":"W2081744051","doi":"10.1038/mt.2011.21","title":"RNAi-based Therapeutics Targeting Survivin and PLK1 for Treatment of Bladder Cancer","year":2011,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Survivin; RNA interference; PLK1; Bladder cancer; Cancer research; Cancer; Medicine; Biology; Internal medicine; Cell cycle; Gene; Genetics; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009859997,0.0001586464,0.0001596543,0.00002587681,0.00004674818,0.000007490225,0.00008487047,0.0001036849,0.00005511434],"category_scores_gemma":[0.00000507345,0.0001314037,0.0001072861,0.00003765414,0.00006776459,0.000001537833,0.0000109437,0.00001737631,7.974372e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000823658,"about_ca_system_score_gemma":0.00006123684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000762903,"about_ca_topic_score_gemma":0.0000153387,"domain_scores_codex":[0.9992985,0.00005972553,0.0001461068,0.0002389841,0.0000675366,0.0001891227],"domain_scores_gemma":[0.9995828,0.00001072691,0.00007806643,0.0002088011,0.00007448391,0.00004507352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000312052,0.000159006,0.001809963,0.00001266195,0.0002023301,0.000001096024,0.000262141,0.000008602545,0.9746184,0.00006287831,0.00002285895,0.02252804],"study_design_scores_gemma":[0.001521938,0.00128725,0.0004653818,0.000006258287,0.00002413928,8.119184e-7,0.00003124361,0.00009439407,0.9711669,0.0001489213,0.02509857,0.000154155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780291,0.01279721,0.008151378,0.00007028406,0.00006506583,0.0004882244,0.00005295954,0.00001010405,0.0003356882],"genre_scores_gemma":[0.9937137,0.00185432,0.003542518,0.0004609307,0.00006068372,0.0001806695,0.0000517932,0.00003763827,0.00009769308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02507572,"threshold_uncertainty_score":0.5358488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05700986241924001,"score_gpt":0.2890758528448251,"score_spread":0.2320659904255851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}