{"id":"W2081745303","doi":"10.1016/j.celrep.2014.05.008","title":"XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation","year":2014,"lang":"en","type":"article","venue":"Cell Reports","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":266,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novo Nordisk Fonden; Human Frontier Science Program; Lundbeckfonden; Bundesministerium für Bildung und Forschung; Natural Sciences and Engineering Research Council of Canada; Deutsche Krebshilfe; Wilhelm Sander-Stiftung; Natur og Univers, Det Frie Forskningsråd","keywords":"Inflammasome; XIAP; Cell biology; Programmed cell death; Tumor necrosis factor alpha; Chemistry; Cell survival; Cancer research; Apoptosis; Biology; Inflammation; Caspase; Immunology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002047989,0.0001482014,0.0001214787,0.00004439149,0.00009615129,0.00003950698,0.00004711286,0.0001495908,0.00000776959],"category_scores_gemma":[0.00007703574,0.0001437964,0.00003362224,0.00003831808,0.00003365635,0.0000097987,0.0001036528,0.00008263097,0.000003253084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007301194,"about_ca_system_score_gemma":0.00003688956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002753933,"about_ca_topic_score_gemma":0.000003504558,"domain_scores_codex":[0.9990532,0.00003479879,0.0002380074,0.0003629217,0.0001092959,0.0002017619],"domain_scores_gemma":[0.9993616,0.00001085832,0.0001669665,0.0003353555,0.00005113455,0.00007404333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002430878,0.00003097247,0.01577483,0.00004141241,0.000009789591,0.00001398144,0.00005872081,0.00001784201,0.9806019,0.00001936003,0.0003685869,0.0030383],"study_design_scores_gemma":[0.0003919976,0.000152807,0.01549316,0.000008727605,0.00001613619,0.00004830191,0.00005315954,0.0000239812,0.9331813,0.0002280397,0.05020211,0.0002002048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812437,0.0006110821,0.0002744642,0.00003818992,0.0001141671,0.0001497371,5.685553e-7,0.00001277835,0.01755535],"genre_scores_gemma":[0.9962637,0.000471741,0.0001502709,0.0001127808,0.0001002405,0.00001172301,0.00006279532,0.00002006572,0.0028067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04983353,"threshold_uncertainty_score":0.5863845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005085093119463848,"score_gpt":0.199613474756849,"score_spread":0.1945283816373852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}