{"id":"W2081745303","doi":"10.1016/j.celrep.2014.05.008","title":"XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation","year":2014,"lang":"en","type":"article","venue":"Cell Reports","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":266,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novo Nordisk Fonden; Human Frontier Science Program; Lundbeckfonden; Bundesministerium für Bildung und Forschung; Natural Sciences and Engineering Research Council of Canada; Deutsche Krebshilfe; Wilhelm Sander-Stiftung; Natur og Univers, Det Frie Forskningsråd","keywords":"Inflammasome; XIAP; Cell biology; Programmed cell death; Tumor necrosis factor alpha; Chemistry; Cell survival; Cancer research; Apoptosis; Biology; Inflammation; Caspase; Immunology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001621832,0.0002839529,0.0002164462,0.0002098771,0.000116455,0.0003734192,0.0001280673,0.0001804704,0.00133081],"category_scores_gemma":[0.0001648594,0.00009912021,0.0002441667,0.0001503551,0.0001943069,0.0002210308,0.0003495592,0.0004003358,0.0004050717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000198841,"about_ca_system_score_gemma":0.0001637989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001509701,"about_ca_topic_score_gemma":0.0002095857,"domain_scores_codex":[0.9998428,0.00003049103,0.00002005326,0.00002809748,0.00003328864,0.00004529324],"domain_scores_gemma":[0.9998598,0.00002437752,0.00004394637,0.00002919405,0.000009746912,0.00003279778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001614415,0.00001749356,0.0002193733,0.00002995372,0.000004375363,0.0000717923,0.000008811418,0.00003885434,0.998133,0.00006806149,0.00004196871,0.001204884],"study_design_scores_gemma":[0.00004969499,0.000351779,0.004391094,0.000008451771,0.0000135779,0.0009513294,0.00002485557,0.0004502593,0.9901503,0.0001041981,0.003500397,0.000004016024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906977,0.004251911,0.002468063,0.0001288713,0.00002875724,0.00002701562,0.0003665715,0.0001037027,0.001927444],"genre_scores_gemma":[0.9965937,0.0009094962,0.001085178,0.00004589288,0.00001099423,0.00002556731,0.0003465986,0.00001462454,0.0009678324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00133081,"threshold_uncertainty_score":0.00445205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005085093119463848,"score_gpt":0.199613474756849,"score_spread":0.1945283816373852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}