{"id":"W2081767887","doi":"10.1016/s0002-9440(10)64604-4","title":"Spontaneous Classical Pathway Activation and Deficiency of Membrane Regulators Render Human Neurons Susceptible to Complement Lysis","year":2000,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":136,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"Wellcome Trust","keywords":"Lysis; Complement (music); Complement system; Classical complement pathway; Cell biology; Alternative complement pathway; Complement membrane attack complex; Chemistry; Decay-accelerating factor; Biology; Immunology; Biochemistry; Antibody; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001794557,0.0003740386,0.0003241113,0.0003189201,0.0001893278,0.0003357447,0.000310609,0.0005188566,0.001965091],"category_scores_gemma":[0.0004644698,0.0002122606,0.000284826,0.000229182,0.0004428557,0.0002171109,0.00034579,0.0005600767,0.0004138373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004346119,"about_ca_system_score_gemma":0.0003691899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001538685,"about_ca_topic_score_gemma":0.001601877,"domain_scores_codex":[0.9997794,0.00003470646,0.00002470154,0.00003858501,0.0000493699,0.00007324844],"domain_scores_gemma":[0.9997104,0.00008382921,0.00005445312,0.00006923331,0.0000209014,0.00006124104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005940397,0.00006968597,0.0006867659,0.00002052834,0.00002261525,0.0004486007,0.00003454822,0.0001408498,0.9965621,0.000292159,0.00006967554,0.001058529],"study_design_scores_gemma":[0.0001083289,0.001021867,0.01219803,0.000008915103,0.00006339562,0.00347224,0.0001523155,0.001307766,0.9797758,0.0004336553,0.001441054,0.00001660701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979145,0.0003256575,0.0008161164,0.00005073777,0.0000171996,0.00002376973,0.0002146229,0.00003558214,0.0006016936],"genre_scores_gemma":[0.9986122,0.0001588309,0.0003113161,0.00001723964,0.000004024471,0.0000164495,0.0001842413,0.00001231013,0.0006833163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001965091,"threshold_uncertainty_score":0.006573856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01152923153489872,"score_gpt":0.2569802940191303,"score_spread":0.2454510624842315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}