{"id":"W2081774969","doi":"10.1016/s0197-0186(02)00073-6","title":"Mechanisms of metabotropic glutamate receptor desensitization: role in the patterning of effector enzyme activation","year":2002,"lang":"en","type":"review","venue":"Neurochemistry International","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Metabotropic glutamate receptor; G protein-coupled receptor; G protein-coupled receptor kinase; Metabotropic glutamate receptor 7; Cell biology; Metabotropic glutamate receptor 6; Biology; Metabotropic glutamate receptor 2; Homologous desensitization; Metabotropic glutamate receptor 1; G protein; Class C GPCR; Metabotropic glutamate receptor 5; Protein kinase C; Neuroscience; Chemistry; Glutamate receptor; Signal transduction; Receptor; Desensitization (medicine); Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000186875,0.0002632075,0.0005006967,0.00007909977,0.00002572597,0.00002147733,0.0005256389,0.0002658239,0.0003183141],"category_scores_gemma":[0.0001401908,0.0002117228,0.0002961092,0.0001248118,0.00003151543,0.000006698423,0.00009236068,0.0002182301,0.000006516138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002446389,"about_ca_system_score_gemma":0.00005281695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005195002,"about_ca_topic_score_gemma":5.192244e-7,"domain_scores_codex":[0.9984017,0.000160314,0.0005855149,0.0003521198,0.000353961,0.0001463594],"domain_scores_gemma":[0.9988673,0.00007331024,0.0005956452,0.0003035626,0.0001335118,0.0000267153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001710665,0.00008840724,0.000004470397,0.001565959,0.0001218631,0.000002495186,0.00003316544,0.00004512475,0.9625373,0.00009934741,0.0001916411,0.03529311],"study_design_scores_gemma":[0.0002742328,0.0001038732,0.00000442493,0.001856814,0.000101032,0.00002810381,0.00003687498,0.00009239864,0.7099037,0.00005190027,0.287299,0.0002475768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03569933,0.9368449,0.02129042,0.0001388489,0.002225117,0.001583513,0.0006370055,0.0000364273,0.001544372],"genre_scores_gemma":[0.1348199,0.8603671,0.0009544356,0.0001035964,0.0007227873,0.0001393726,0.002402131,0.00009355225,0.0003971986],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.2871074,"threshold_uncertainty_score":0.8633804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01837305943958698,"score_gpt":0.2701489886738134,"score_spread":0.2517759292342264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}