{"id":"W2081783238","doi":"10.1126/scisignal.2004113","title":"BIM, PUMA, and the Achilles’ Heel of Oncogene Addiction","year":2013,"lang":"en","type":"review","venue":"Science Signaling","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Oncogene; Epigenetics; Phenotype; Biology; Cancer research; Addiction; Puma; Cancer; CRISPR; Medicine; Neuroscience; Genetics; Apoptosis; Gene; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006248998,0.0006025152,0.00104556,0.001593728,0.0003315883,0.0009661475,0.0007129099,0.001227487,0.002470432],"category_scores_gemma":[0.0005476089,0.0002794123,0.0002823895,0.0012243,0.0009504547,0.001786887,0.0006954472,0.00259519,0.001581754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008406679,"about_ca_system_score_gemma":0.0009018201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008876108,"about_ca_topic_score_gemma":0.00228905,"domain_scores_codex":[0.9998395,0.00003623178,0.00001520601,0.0000230832,0.0000653876,0.00002045265],"domain_scores_gemma":[0.999797,0.00009977061,0.00002099921,0.000008789645,0.00004593049,0.00002750572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000932045,0.00006346049,0.000179305,0.005191601,0.00005917442,0.0002999265,0.0000724296,0.0003778008,0.002252007,0.02198761,0.04882606,0.9205973],"study_design_scores_gemma":[0.00001312288,0.00004208108,0.0003558601,0.001105998,0.0000201674,0.0009573938,0.0000551605,0.00006270224,0.0003849929,0.006910524,0.99008,0.00001209709],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001138389,0.9980084,0.0001081803,0.000710505,0.0001859315,0.000001578186,0.000007127245,0.000006348104,0.0008581874],"genre_scores_gemma":[0.001059328,0.9973071,0.0001225212,0.0003898917,0.0002224693,0.000004397542,0.00001320498,0.000001451369,0.0008796671],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002470432,"threshold_uncertainty_score":0.008264422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07743560108723829,"score_gpt":0.3883877242185418,"score_spread":0.3109521231313035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}