{"id":"W2081783238","doi":"10.1126/scisignal.2004113","title":"BIM, PUMA, and the Achilles’ Heel of Oncogene Addiction","year":2013,"lang":"en","type":"review","venue":"Science Signaling","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Oncogene; Epigenetics; Phenotype; Biology; Cancer research; Addiction; Puma; Cancer; CRISPR; Medicine; Neuroscience; Genetics; Apoptosis; Gene; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003362908,0.0002119558,0.001029979,0.000414353,0.0002077098,0.00007874831,0.0004244279,0.0001212184,0.001233608],"category_scores_gemma":[0.0003357401,0.0001124902,0.0002642129,0.001227051,0.002003109,0.0001068444,0.0001803484,0.0004712988,0.00004130499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000134998,"about_ca_system_score_gemma":0.0009590049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000102721,"about_ca_topic_score_gemma":0.000001417035,"domain_scores_codex":[0.9975709,0.0001660707,0.0004714901,0.0004404706,0.0009891312,0.0003619527],"domain_scores_gemma":[0.998443,0.0003924515,0.0002608007,0.0005008494,0.0002366986,0.0001661885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001911279,0.00001574446,0.000002065887,0.001352157,0.00005628911,0.00000225369,0.0001193703,0.000001001588,0.00570112,0.0002100496,0.00003586861,0.992485],"study_design_scores_gemma":[0.001057615,0.0001905289,0.000004624775,0.009787855,0.0005908948,0.0001966498,0.0001389745,0.000256289,0.001734899,0.0001356303,0.9856861,0.0002199891],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005654847,0.9948918,0.00005047285,0.00008221701,0.0001697078,0.001382373,0.000007404442,0.00001898155,0.002831538],"genre_scores_gemma":[0.0006268929,0.9972773,0.0002766336,0.00003797408,0.0002515016,0.00007418094,0.000007929609,0.0000254016,0.001422206],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.992265,"threshold_uncertainty_score":0.9996794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07743560108723829,"score_gpt":0.3883877242185418,"score_spread":0.3109521231313035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}