{"id":"W2081802283","doi":"10.1073/pnas.0409402102","title":"Disturbed Ca <sup>2+</sup> signaling and apoptosis of medium spiny neurons in Huntington's disease","year":2005,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":360,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; Cure Huntington's Disease Initiative; Hereditary Disease Foundation; Canadian Institutes of Health Research; Welch Foundation","keywords":"Mitochondrial permeability transition pore; MPTP; Medium spiny neuron; Cell biology; Glutamate receptor; Biology; Apoptosis; Huntington's disease; Cytochrome c; Chemistry; Mitochondrion; Biochemistry; Programmed cell death; Receptor; Neuroscience; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009366298,0.0002444923,0.0002176959,0.0002408942,0.0001458626,0.0002031113,0.0002017924,0.0003109566,0.0005538424],"category_scores_gemma":[0.00007899569,0.0001379821,0.0001906729,0.0001537709,0.0002458298,0.0002251787,0.0002158704,0.0004359542,0.000152604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002022677,"about_ca_system_score_gemma":0.0001021479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003665567,"about_ca_topic_score_gemma":0.0005733933,"domain_scores_codex":[0.9999367,0.000006316569,0.00001273212,0.00001387847,0.00002080989,0.000009437662],"domain_scores_gemma":[0.9999218,0.00001082266,0.00003252433,0.000006161804,0.000009606267,0.00001903846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003991543,0.00002217858,0.001862268,0.00004087771,0.00000913645,0.0004427581,0.00001728501,0.00003047953,0.9960952,0.00005622331,0.000021511,0.001002868],"study_design_scores_gemma":[0.00009071162,0.0009238918,0.1148428,0.00001462935,0.00007269196,0.005662581,0.00009948746,0.0008736827,0.8750533,0.0003129669,0.00204185,0.00001137649],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975062,0.001270323,0.0006637985,0.00005533451,0.000008938358,0.000008800916,0.0001253331,0.00001681786,0.0003445344],"genre_scores_gemma":[0.9972774,0.0007303295,0.001000536,0.0000398873,0.000007359624,0.0000246449,0.0002759028,0.000006734585,0.0006370776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005538424,"threshold_uncertainty_score":0.00185281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03648751398554717,"score_gpt":0.2925185441667298,"score_spread":0.2560310301811827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}