{"id":"W2081820338","doi":"10.1038/ncomms7139","title":"Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":286,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo; Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; National Cancer Institute; Servier; Indo-US Science and Technology Forum","keywords":"Taxane; Cancer research; CD44; Chemotherapy; Cancer cell; Biology; Cancer; Kinase; Phenotype; Cell biology; Cell; Breast cancer; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006070297,0.0001879102,0.0003304472,0.0000779908,0.0002638889,0.00003105515,0.0003915171,0.0002359509,0.00005756382],"category_scores_gemma":[0.0001234348,0.0001760647,0.0001050462,0.0005102035,0.000118105,0.0001847339,0.00005140016,0.001209706,0.00001544449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003567273,"about_ca_system_score_gemma":0.0003948378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002830592,"about_ca_topic_score_gemma":0.0002918554,"domain_scores_codex":[0.9985822,0.0001889006,0.0003033841,0.0002870598,0.000377892,0.000260599],"domain_scores_gemma":[0.9979054,0.0001246993,0.0001456412,0.001197333,0.000424901,0.0002020138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002720486,0.001552032,0.0008464624,0.0002034975,0.0006991486,0.00001188645,0.02056101,0.00004731526,0.5572552,0.01163936,0.3895973,0.01486631],"study_design_scores_gemma":[0.009145142,0.0004100215,0.001210351,0.000556052,0.0004626224,0.00001478537,0.006386348,0.001148813,0.05900386,0.001924345,0.918788,0.000949658],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4415624,0.2013506,0.005548975,0.1873907,0.001288048,0.004697476,0.0007145207,0.001067481,0.1563798],"genre_scores_gemma":[0.9712041,0.0009313282,0.02270981,0.003476569,0.0001041856,0.00007778811,0.0002699464,0.0000382543,0.001188043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5296417,"threshold_uncertainty_score":0.7179711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.034885844323643,"score_gpt":0.3173038960890273,"score_spread":0.2824180517653843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}