{"id":"W2081848717","doi":"10.1002/bies.200800189","title":"Reprogramming cell fates: reconciling rarity with robustness","year":2009,"lang":"en","type":"article","venue":"BioEssays","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":328,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Air Force Office of Scientific Research; National Cancer Institute; U.S. Air Force; National Institutes of Health","keywords":"Reprogramming; Biology; Induced pluripotent stem cell; Cell fate determination; Gene regulatory network; Robustness (evolution); Somatic cell; Epigenetics; Computational biology; Cellular differentiation; Stem cell; Phenotype; Cell biology; Genetics; Gene; Gene expression; Transcription factor; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004485188,0.0003860702,0.0007505464,0.0008019151,0.0008232783,0.00276645,0.001345113,0.001666936,0.001061448],"category_scores_gemma":[0.01369036,0.0004107274,0.0005832188,0.0003697676,0.01205182,0.007122555,0.004161221,0.002834309,0.0002372699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001169826,"about_ca_system_score_gemma":0.000522903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002368786,"about_ca_topic_score_gemma":0.0002242741,"domain_scores_codex":[0.9978874,0.0007404601,0.0001261644,0.0004161707,0.0006503828,0.0001793915],"domain_scores_gemma":[0.9922417,0.004836634,0.0008560802,0.001586805,0.0002592925,0.0002195423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0000522013,0.00001434095,0.001740386,0.0001465343,0.00003373746,0.0002658157,0.0009412655,0.02757771,0.01710714,0.9268726,0.0003784455,0.02486988],"study_design_scores_gemma":[0.00001393094,0.00005237267,0.0009241372,0.00003919121,0.00001726379,0.0003559338,0.0002303095,0.03164034,0.004573891,0.9579291,0.004189489,0.00003394564],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2239139,0.004902634,0.7338532,0.0131672,0.0002409955,0.00004479541,0.00008110937,0.000439534,0.02335661],"genre_scores_gemma":[0.9624188,0.00149103,0.03361989,0.0006190204,0.0002039056,0.00007396832,0.00003273652,0.00009157855,0.001449128],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004485188,"threshold_uncertainty_score":0.02372026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0165749312293913,"score_gpt":0.2550122470860464,"score_spread":0.2384373158566551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}