{"id":"W2081848717","doi":"10.1002/bies.200800189","title":"Reprogramming cell fates: reconciling rarity with robustness","year":2009,"lang":"en","type":"article","venue":"BioEssays","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":328,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Air Force Office of Scientific Research; National Cancer Institute; U.S. Air Force; National Institutes of Health","keywords":"Reprogramming; Biology; Induced pluripotent stem cell; Cell fate determination; Gene regulatory network; Robustness (evolution); Somatic cell; Epigenetics; Computational biology; Cellular differentiation; Stem cell; Phenotype; Cell biology; Genetics; Gene; Gene expression; Transcription factor; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003377595,0.0001642585,0.0001416339,0.00004371568,0.0001176213,0.00005728958,0.0002629151,0.0001528937,0.0000187853],"category_scores_gemma":[0.00003823281,0.0001365042,0.00006323541,0.0001460291,0.00007009433,0.000005749725,0.00006612635,0.0001423521,0.00001656999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002054276,"about_ca_system_score_gemma":0.00008455759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001769591,"about_ca_topic_score_gemma":0.0000175313,"domain_scores_codex":[0.998646,0.00006045971,0.0001661875,0.0005076584,0.00021211,0.000407542],"domain_scores_gemma":[0.9991774,0.00001003558,0.00006426187,0.0005093649,0.0001147706,0.0001241487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002562975,0.0002373363,0.005872314,0.0000614726,0.00003231517,0.00006068056,0.00004477067,0.0008211325,0.9703887,0.00004019697,0.001051099,0.02113372],"study_design_scores_gemma":[0.001151491,0.0009576925,0.001617044,0.00004382001,0.00001923457,0.00004751435,0.0001670605,0.0007052313,0.9739004,0.00004875924,0.02087573,0.0004660763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798777,0.0008937647,0.007583618,0.0003416281,0.00006741212,0.0002858717,0.000006937549,0.00004922191,0.01089383],"genre_scores_gemma":[0.9932489,0.0001219944,0.0045422,0.0001112872,0.0001652008,0.00001288525,0.00007610436,0.00001875529,0.001702644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02066764,"threshold_uncertainty_score":0.556648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0165749312293913,"score_gpt":0.2550122470860464,"score_spread":0.2384373158566551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}