{"id":"W2081854990","doi":"10.1177/0091270010391790","title":"N‐acetylcysteine as a Novel Prophylactic Treatment for Ifosfamide‐Induced Nephrotoxicity in Children: Translational Pharmacokinetics","year":2011,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"Chemotherapy-induced organ toxicity mitigation","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Children's Hospital of Western Ontario; London Health Sciences Centre; McMaster University; Royal College of Physicians and Surgeons of Canada; Hospital for Sick Children; Lawson Health Research Institute; University of Waterloo; Western University","funders":"Canadian Institutes of Health Research","keywords":"Nephrotoxicity; Acetylcysteine; Medicine; Ifosfamide; Antidote; Pharmacokinetics; Acetaminophen; acetaminophen overdose; Pharmacology; Chemotherapy; Cisplatin; Toxicity; Internal medicine; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002702523,0.0002155419,0.0003130704,0.0002034363,0.0001232231,0.0003301385,0.0001944653,0.0001921976,0.0006791251],"category_scores_gemma":[0.0002453594,0.00007402335,0.0001760557,0.0002232516,0.0002390111,0.0003094383,0.0001353368,0.0005025594,0.0001112304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000520527,"about_ca_system_score_gemma":0.0006573453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009142712,"about_ca_topic_score_gemma":0.002731838,"domain_scores_codex":[0.9999067,0.00003423295,0.000008027845,0.0000146298,0.00002291358,0.00001362186],"domain_scores_gemma":[0.9998776,0.00001813204,0.00005471586,0.000008604989,0.00002021023,0.00002069181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.005403376,0.002919793,0.02233152,0.001657824,0.0002300229,0.001448214,0.0003526558,0.001548767,0.3702353,0.003547666,0.002692885,0.587632],"study_design_scores_gemma":[0.003013442,0.07655557,0.2099772,0.0006935433,0.0009167527,0.01947507,0.0007877522,0.007562669,0.4145338,0.002023841,0.2643563,0.0001041238],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8847857,0.1009149,0.004822905,0.0019682,0.0001410546,0.0001921167,0.0001514823,0.00009041563,0.006933304],"genre_scores_gemma":[0.9440167,0.04677605,0.007192172,0.0003440702,0.0001011705,0.00006817807,0.0001422908,0.00001508762,0.001344262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009142712,"threshold_uncertainty_score":0.003776729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1578557720616258,"score_gpt":0.4380165653200491,"score_spread":0.2801607932584233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}