{"id":"W2081863728","doi":"10.1210/en.2005-0082","title":"Insulin Receptor Kinase-Associated Phosphotyrosine Phosphatases in Hepatic Endosomes: Assessing the Role of Phosphotyrosine Phosphatase-1B","year":2005,"lang":"en","type":"article","venue":"Endocrinology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"McGill University","keywords":"Endosome; Dephosphorylation; Phosphatase; Insulin receptor; Biology; Insulin; Endocrinology; Cell biology; Chemistry; Phosphorylation; Molecular biology; Receptor; Internal medicine; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004551646,0.0006203519,0.0007581985,0.0001802644,0.0002152961,0.00006657557,0.001030546,0.0003099957,0.0003513543],"category_scores_gemma":[0.001048069,0.0005391445,0.0002371344,0.0007031393,0.0006024582,0.00005884733,0.000546925,0.0004830412,0.00008875995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001596188,"about_ca_system_score_gemma":0.0002822777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001255031,"about_ca_topic_score_gemma":0.0004975445,"domain_scores_codex":[0.9959505,0.0003403655,0.00112909,0.0009466559,0.0004068352,0.001226618],"domain_scores_gemma":[0.9975682,0.0002318953,0.0006288991,0.001205892,0.0002027166,0.0001623751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001422365,0.004742745,0.08333219,0.0001395922,0.000685044,0.0001180617,0.0005592924,0.001146136,0.6827959,0.02150917,0.01470775,0.1888418],"study_design_scores_gemma":[0.002931796,0.0004215219,0.007121183,0.00009606025,0.00005689908,0.00003587021,0.0002524582,0.0002091326,0.8933263,0.0003139758,0.09474456,0.0004902238],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7179463,0.2784433,0.0000957377,0.0007313099,0.0004057271,0.0009304759,0.0009646845,0.00009274559,0.0003897214],"genre_scores_gemma":[0.9901261,0.004473776,0.001900367,0.0007568597,0.0002298652,0.0002800137,0.001978606,0.0000984929,0.0001559741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2739696,"threshold_uncertainty_score":0.999706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007887510250002566,"score_gpt":0.2544598946313387,"score_spread":0.2465723843813362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}