{"id":"W2081870901","doi":"10.1002/bdra.20781","title":"Epigenetic programming: From gametes to blastocyst","year":2011,"lang":"en","type":"review","venue":"Birth Defects Research Part A Clinical and Molecular Teratology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Epigenetics; Biology; Blastocyst; DNA methylation; Chromatin; Embryo; Histone; Genetics; Epigenesis; Gametogenesis; Cell fate determination; Embryogenesis; Cell biology; DNA; Gene expression; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001838266,0.0005983341,0.001687775,0.0003262418,0.0001808853,0.0001249652,0.0006262357,0.001291256,0.00005332314],"category_scores_gemma":[0.002268647,0.0005038024,0.0006440707,0.0004326624,0.0006604741,0.000003493582,0.001007997,0.0009047526,0.0002139202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001488169,"about_ca_system_score_gemma":0.0004876297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004523107,"about_ca_topic_score_gemma":0.000110238,"domain_scores_codex":[0.9927424,0.002829608,0.001244855,0.001815633,0.000341507,0.00102601],"domain_scores_gemma":[0.9969165,0.0005205916,0.0002442398,0.001164937,0.000326192,0.0008275378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008254446,0.0002733119,0.0006679874,0.001205334,0.0004050395,0.0001057233,0.00002341927,3.213912e-7,0.0006884931,0.0002129342,0.0006518707,0.995683],"study_design_scores_gemma":[0.0003657383,0.002120701,0.0000499053,0.0008949155,0.000183812,0.00001361934,0.000005546838,0.000001250234,0.001450911,0.0004369875,0.993948,0.0005285433],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0187413,0.9775524,0.0009546287,0.00003720709,0.0003690655,0.001868605,0.00009424202,0.00002659002,0.0003559458],"genre_scores_gemma":[0.002606745,0.9931522,0.001890932,0.0001603547,0.0005621348,0.0006995567,0.0004498276,0.0001269456,0.000351276],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9951545,"threshold_uncertainty_score":0.9997414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1917355799844427,"score_gpt":0.4698948969095747,"score_spread":0.278159316925132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}