{"id":"W2081870901","doi":"10.1002/bdra.20781","title":"Epigenetic programming: From gametes to blastocyst","year":2011,"lang":"en","type":"review","venue":"Birth Defects Research Part A Clinical and Molecular Teratology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Epigenetics; Biology; Blastocyst; DNA methylation; Chromatin; Embryo; Histone; Genetics; Epigenesis; Gametogenesis; Cell fate determination; Embryogenesis; Cell biology; DNA; Gene expression; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004074387,0.0007451784,0.000938238,0.001414726,0.0003060995,0.0008073047,0.0009238406,0.001196016,0.003158875],"category_scores_gemma":[0.0004664115,0.0002339047,0.0002078639,0.001173169,0.0008245367,0.001253091,0.0006347159,0.001190979,0.003212861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006872634,"about_ca_system_score_gemma":0.000722131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009027627,"about_ca_topic_score_gemma":0.001055325,"domain_scores_codex":[0.9998702,0.00002208623,0.00001916627,0.00003002595,0.00004617744,0.00001239305],"domain_scores_gemma":[0.9998534,0.00005136417,0.00002466615,0.000006445089,0.00004121497,0.00002282508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005330327,0.00003200126,0.0002164797,0.006820584,0.00003170061,0.0006186798,0.00009092563,0.0003196114,0.004178387,0.008059393,0.02663798,0.9529409],"study_design_scores_gemma":[0.000009091457,0.00004380369,0.0008125077,0.0009004467,0.00003019457,0.002737756,0.00006758914,0.00006572371,0.002023061,0.002773726,0.9905218,0.00001439658],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002141271,0.9961254,0.00068802,0.0003509423,0.0002881073,0.000006821616,0.00002885419,0.0000235369,0.002274147],"genre_scores_gemma":[0.001518334,0.9959675,0.0004372265,0.0001740875,0.0002008029,0.000009017052,0.0000309281,0.000003226838,0.001658887],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003158875,"threshold_uncertainty_score":0.01056749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1917355799844427,"score_gpt":0.4698948969095747,"score_spread":0.278159316925132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}