{"id":"W2081894758","doi":"10.1016/s0960-894x(00)00568-0","title":"Substituted 1,6-naphthyridines as human cytomegalovirus inhibitors: conformational requirements","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"BioPhage Pharma (Canada)","funders":"","keywords":"Chemistry; Human cytomegalovirus; Intramolecular force; Hydrogen bond; Stereochemistry; Cytomegalovirus; Combinatorial chemistry; Chemical synthesis; Enzyme inhibitor; Structure–activity relationship; In vitro; Biochemistry; Molecule; Virology; Herpesviridae; Virus; Organic chemistry; Viral disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002990179,0.0003061692,0.0003168493,0.00009741852,0.00014812,0.0002431452,0.0006293488,0.0002960189,0.001593879],"category_scores_gemma":[0.0002793888,0.0001932751,0.0001129816,0.000109307,0.0002099994,0.000518222,0.000225357,0.0005140511,0.0004641473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003332019,"about_ca_system_score_gemma":0.000152951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003472172,"about_ca_topic_score_gemma":0.0008160885,"domain_scores_codex":[0.999879,0.00004056329,0.00001033495,0.00001625345,0.00002720892,0.00002658547],"domain_scores_gemma":[0.9999127,0.0000392286,0.00001815503,0.00001078993,0.000009589429,0.000009576351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000678313,0.0000693622,0.0001024778,0.0001546046,0.00001089805,0.0001894364,0.00009290146,0.002066027,0.9839039,0.002185531,0.0002556108,0.01029098],"study_design_scores_gemma":[0.000117379,0.001012261,0.0004943725,0.00001767302,0.00002127727,0.0004496158,0.00002766708,0.002896485,0.9872706,0.0004037661,0.007267225,0.00002171916],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812386,0.007800061,0.00474208,0.000202128,0.00005055585,0.00006017102,0.0001609552,0.0001413679,0.005603991],"genre_scores_gemma":[0.9891765,0.004867756,0.003112053,0.0001085308,0.00001932377,0.00005971333,0.0002391287,0.00004427913,0.002372733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001593879,"threshold_uncertainty_score":0.005332112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008891678838311046,"score_gpt":0.2458099024277308,"score_spread":0.2369182235894198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}