{"id":"W2081918559","doi":"10.1021/bi401156a","title":"A Substrate-Assisted Mechanism of Nucleophile Activation in a Ser–His–Asp Containing C–C Bond Hydrolase","year":2013,"lang":"en","type":"article","venue":"Biochemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Center for Research Resources; National Institute of General Medical Sciences","keywords":"Hydrolase; Mechanism (biology); Nucleophile; Chemistry; Substrate (aquarium); Stereochemistry; Substrate specificity; Enzyme; Combinatorial chemistry; Biochemistry; Catalysis; Biology; Philosophy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001565808,0.0002024806,0.000206562,0.00005272814,0.00003870768,0.00002688539,0.0002627891,0.0003633416,0.00008746209],"category_scores_gemma":[0.0001430919,0.0002043527,0.0001098693,0.0001876205,0.0001061238,0.00000788749,0.0001508629,0.0001913054,0.00001434059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003469794,"about_ca_system_score_gemma":0.0001280641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001936182,"about_ca_topic_score_gemma":0.000008202444,"domain_scores_codex":[0.9986119,0.00003413407,0.0003262234,0.0004489424,0.0002206707,0.0003581388],"domain_scores_gemma":[0.9991686,0.00001435516,0.0001179379,0.0004109755,0.0001402705,0.0001478679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000114024,0.0001527671,0.0005272998,0.00008220047,0.00003037631,0.000003954087,0.00002018757,0.00000157415,0.9977062,0.00007449243,0.0007107726,0.0005761641],"study_design_scores_gemma":[0.0008323909,0.0001459439,0.001295235,0.0000589907,0.00000587359,0.00001096242,0.0001370446,0.0001017463,0.9967403,0.0002639111,0.0001858883,0.0002216627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969047,0.0001658973,0.0002121453,0.0001916526,0.00002357382,0.0002618883,0.00001268816,0.00001451771,0.002212911],"genre_scores_gemma":[0.9986145,0.00002128397,0.0004608092,0.0001426485,0.00007026208,0.00008483344,0.0002285324,0.0000285016,0.0003486304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001864281,"threshold_uncertainty_score":0.833326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01214964807648877,"score_gpt":0.2448097939228642,"score_spread":0.2326601458463754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}