{"id":"W2081931905","doi":"10.1371/journal.pone.0071075","title":"Impaired Ca2+ Signaling in β-Cells Lacking Leptin Receptors by Cre-loxP Recombination","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Cre-Lox recombination; Receptor; Cell biology; Leptin; Biology; Genetics; Endocrinology; Transgene; Gene; Obesity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007246679,0.0008478601,0.0007762178,0.0006441317,0.0002177121,0.0009654476,0.001037743,0.0009357909,0.001727518],"category_scores_gemma":[0.00038055,0.0005693522,0.000551406,0.0003840892,0.0004861407,0.0006227864,0.0005326061,0.001622162,0.001181429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002651691,"about_ca_system_score_gemma":0.0003475081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003974227,"about_ca_topic_score_gemma":0.0005210901,"domain_scores_codex":[0.9993224,0.00008995697,0.000149789,0.0001806525,0.0001408655,0.0001163854],"domain_scores_gemma":[0.9994822,0.00008156538,0.0002182195,0.0000813637,0.00004234225,0.00009436932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006463757,0.00001946921,0.00006528857,0.00003921069,0.000006320028,0.00007041151,0.00001850655,0.00003042212,0.9989454,0.00008741103,0.00002458275,0.0006283962],"study_design_scores_gemma":[0.0001098156,0.000329721,0.002219709,0.00003639958,0.00005427107,0.001231922,0.00004610399,0.001040834,0.9864049,0.0001221239,0.008389927,0.00001419289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9331904,0.005999845,0.05247086,0.0004307393,0.0003299456,0.0004190263,0.00285976,0.001111206,0.003188254],"genre_scores_gemma":[0.9266188,0.007836507,0.04914816,0.0003512817,0.00007818599,0.000731913,0.005212312,0.0005847035,0.009438076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001727518,"threshold_uncertainty_score":0.005779147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04511716934430614,"score_gpt":0.2275951346531881,"score_spread":0.182477965308882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}