{"id":"W2081985037","doi":"10.4161/cbt.25089","title":"<i>Cables1</i>is a tumor suppressor gene that regulates intestinal tumor progression in<i>Apc<sup>Min</sup></i>mice","year":2013,"lang":"en","type":"article","venue":"Cancer Biology & Therapy","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Royal College of Physicians and Surgeons of Canada; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; Massachusetts General Hospital","keywords":"Adenomatous polyposis coli; Biology; Cancer research; Oncogene; Wnt signaling pathway; Tumor progression; Tumor suppressor gene; Adenocarcinoma; Colorectal cancer; Catenin; Beta-catenin; Proliferating cell nuclear antigen; Molecular biology; Carcinogenesis; Cancer; Cell cycle; Immunology; Signal transduction; Immunohistochemistry; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001756717,0.0007866459,0.0003102234,0.0008979196,0.0002395468,0.000362242,0.0003383908,0.0004586029,0.002775024],"category_scores_gemma":[0.000132456,0.0003801927,0.00032804,0.0002973826,0.0004106346,0.0002084822,0.000231743,0.0009804934,0.0008382222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004427481,"about_ca_system_score_gemma":0.0002517591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009141118,"about_ca_topic_score_gemma":0.001214141,"domain_scores_codex":[0.999744,0.00003791214,0.00002705322,0.00006537736,0.00007056464,0.0000550396],"domain_scores_gemma":[0.9994705,0.00003784254,0.0002920366,0.00002221582,0.00002591562,0.0001514448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002298272,0.00003541246,0.0004485571,0.00002424686,0.00000656746,0.00007457406,0.00001055659,0.00005106246,0.998078,0.00008650883,0.00006528136,0.0008893836],"study_design_scores_gemma":[0.0001186758,0.0006668661,0.02044447,0.00002747442,0.00005233855,0.001492639,0.00007061895,0.00141244,0.9692475,0.00006754096,0.006384532,0.00001492875],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914171,0.001015509,0.00413234,0.0001680158,0.00003581908,0.00005851257,0.001321153,0.0002900755,0.001561493],"genre_scores_gemma":[0.9821656,0.001743419,0.005282749,0.00009279865,0.00003349766,0.0001337269,0.002392478,0.0002086075,0.007947017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002775024,"threshold_uncertainty_score":0.009283364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02229791742639865,"score_gpt":0.2884971703650769,"score_spread":0.2661992529386783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}