{"id":"W2081985037","doi":"10.4161/cbt.25089","title":"<i>Cables1</i>is a tumor suppressor gene that regulates intestinal tumor progression in<i>Apc<sup>Min</sup></i>mice","year":2013,"lang":"en","type":"article","venue":"Cancer Biology & Therapy","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Royal College of Physicians and Surgeons of Canada; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; Massachusetts General Hospital","keywords":"Adenomatous polyposis coli; Biology; Cancer research; Oncogene; Wnt signaling pathway; Tumor progression; Tumor suppressor gene; Adenocarcinoma; Colorectal cancer; Catenin; Beta-catenin; Proliferating cell nuclear antigen; Molecular biology; Carcinogenesis; Cancer; Cell cycle; Immunology; Signal transduction; Immunohistochemistry; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002635554,0.0004687881,0.000490243,0.0001016897,0.0001609206,0.0000405398,0.0005252816,0.0002455626,0.0001932584],"category_scores_gemma":[0.00006633785,0.0003731602,0.0001509409,0.0001943835,0.0005555154,0.00001462149,0.0002148176,0.0002606832,0.00004568934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005551899,"about_ca_system_score_gemma":0.0001828856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003374091,"about_ca_topic_score_gemma":0.00003559306,"domain_scores_codex":[0.9975346,0.000211904,0.0004153743,0.0009271681,0.0001341898,0.0007767163],"domain_scores_gemma":[0.9988149,0.00005946701,0.0002165845,0.0005525798,0.0002132683,0.0001431303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002647823,0.0001153681,0.04798831,0.00002389216,0.0001409474,0.0000133183,0.0005465783,0.00004669575,0.940653,0.000009406812,0.004351683,0.005845987],"study_design_scores_gemma":[0.001576303,0.0006462703,0.008612503,0.0001212836,0.00001756569,0.00005219207,0.000188738,0.0001351768,0.9534946,0.0003108784,0.03434254,0.0005019454],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751008,0.02269689,0.0000592429,0.0008524755,0.0002354667,0.0007810273,0.00007887533,0.00005692257,0.0001382607],"genre_scores_gemma":[0.9912317,0.001688253,0.001240738,0.003858984,0.0005059835,0.0009892961,0.0001260349,0.00007077611,0.0002882179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0393758,"threshold_uncertainty_score":0.999872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02229791742639865,"score_gpt":0.2884971703650769,"score_spread":0.2661992529386783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}