{"id":"W2081985491","doi":"10.1371/journal.pone.0122743","title":"The Consensus 5' Splice Site Motif Inhibits mRNA Nuclear Export","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Canada Research Chairs","funders":"Canadian Institutes of Health Research","keywords":"RNA splicing; Polyadenylation; Nuclear export signal; Intron; Biology; Exon; Precursor mRNA; RNA; Messenger RNA; Sequence motif; Cell biology; Consensus sequence; Molecular biology; Genetics; Gene; Peptide sequence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002551499,0.0002787412,0.0003522921,0.0001291281,0.0001476262,0.00029256,0.0002340722,0.0002805427,0.002509465],"category_scores_gemma":[0.0003308166,0.0001540298,0.000275471,0.00008603362,0.0002009099,0.0001460214,0.0002739647,0.000446182,0.0008252414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001964666,"about_ca_system_score_gemma":0.0003477321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003912114,"about_ca_topic_score_gemma":0.0008438066,"domain_scores_codex":[0.9997227,0.00005265153,0.00003303615,0.00006113693,0.0000991307,0.00003137374],"domain_scores_gemma":[0.9997408,0.00007103637,0.00007035147,0.00003702693,0.00003245069,0.00004839458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007110534,0.00002046455,0.0002666002,0.00004491127,0.000007121552,0.00004279117,0.000006301162,0.0000620416,0.9968452,0.0001753381,0.00007498884,0.002383068],"study_design_scores_gemma":[0.00002095685,0.0003057248,0.00510527,0.00001358632,0.00001484907,0.0004747995,0.00001228933,0.0007744074,0.9879366,0.0001461155,0.005188532,0.000006888286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822985,0.003860083,0.008742031,0.0001935914,0.0001210457,0.00003114305,0.0003669828,0.0002559617,0.004130705],"genre_scores_gemma":[0.9885554,0.001034275,0.005160112,0.0002440259,0.0000241443,0.00003237793,0.001001988,0.0000579141,0.003889771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002509465,"threshold_uncertainty_score":0.008395016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04950989844017952,"score_gpt":0.2532743413245985,"score_spread":0.2037644428844189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}