{"id":"W2081986994","doi":"10.1158/1538-7445.am2013-4647","title":"Abstract 4647: Tie2-expressing monocytes (TEMs) as potential biomarkers of angiopoietin-Tie2 (Ang/Tie2) directed therapies: correlative analysis of a phase I study of AMG386 + temsirolimus (T).","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Angiopoietin receptor; Angiogenesis; Medicine; Staining; Flow cytometry; Pathology; Immunology; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008074651,0.0003068144,0.0004885433,0.0001866188,0.0001964351,0.0003293184,0.0002207166,0.0003657005,0.002036943],"category_scores_gemma":[0.0003037372,0.0001679062,0.0002353965,0.0001596761,0.0002581929,0.0002166054,0.0001448465,0.00086089,0.0004041154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002525132,"about_ca_system_score_gemma":0.000336663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002393516,"about_ca_topic_score_gemma":0.0003853789,"domain_scores_codex":[0.9997951,0.00009815067,0.00001018257,0.00003423364,0.00002911534,0.00003332816],"domain_scores_gemma":[0.9997222,0.00006484379,0.00005181367,0.00002898537,0.00002682424,0.0001052847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.1115926,0.01284724,0.01986413,0.0004205863,0.000264512,0.0006573128,0.0002136322,0.001362966,0.7903519,0.0002359258,0.002179663,0.06000949],"study_design_scores_gemma":[0.02620386,0.6063808,0.09160191,0.00004776274,0.0005689193,0.003012577,0.0001383684,0.004930108,0.2610433,0.0002566237,0.005788037,0.00002770706],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976078,0.0007444625,0.0003878998,0.00005965538,0.00002091299,0.0002971917,0.0002575178,0.00001548727,0.0006089992],"genre_scores_gemma":[0.9960989,0.0003408875,0.00106999,0.0001385584,0.0000601584,0.0004384239,0.0007691248,0.000007827723,0.001076013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002036943,"threshold_uncertainty_score":0.006814182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04564473454335669,"score_gpt":0.393861673613042,"score_spread":0.3482169390696853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}