{"id":"W2082043656","doi":"10.1186/1471-2407-9-156","title":"A phase II experience with neoadjuvant irinotecan (CPT-11), 5-fluorouracil (5-FU) and leucovorin (LV) for colorectal liver metastases","year":2009,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Hepatocellular Carcinoma Treatment and Prognosis","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Lethbridge College; University of Alberta; University of Calgary","funders":"Canadian Institutes of Health Research; Pfizer Canada; Fondation pour la Recherche Médicale; Pfizer","keywords":"Fluorouracil; Medicine; Irinotecan; Surgical oncology; Internal medicine; Colorectal cancer; Neoadjuvant therapy; Oncology; Chemotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003229002,0.001405104,0.0007989118,0.0002233974,0.0004600072,0.0006631457,0.0007479474,0.0007744093,0.001772484],"category_scores_gemma":[0.001494281,0.0003085619,0.0006576643,0.0002999087,0.0006452694,0.0007399138,0.0004305368,0.001954411,0.0004284639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005429586,"about_ca_system_score_gemma":0.00150793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000594434,"about_ca_topic_score_gemma":0.0009973937,"domain_scores_codex":[0.9991905,0.0004784669,0.00004895899,0.0000924546,0.0000830728,0.0001066315],"domain_scores_gemma":[0.9983612,0.0004606633,0.0002186443,0.00008136255,0.00009196428,0.0007862129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1994807,0.1205757,0.06106497,0.00141693,0.002284109,0.002365202,0.001640697,0.007567723,0.155395,0.0006871486,0.01354669,0.4339752],"study_design_scores_gemma":[0.1306013,0.7975854,0.036052,0.0001087896,0.0006515002,0.003297848,0.0001374153,0.002196049,0.01551594,0.000338915,0.01346595,0.00004897967],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873439,0.005326221,0.002673755,0.0008632001,0.0001436092,0.00127118,0.0005016546,0.00005032034,0.001826168],"genre_scores_gemma":[0.9770834,0.005426558,0.006364093,0.001439342,0.0003356658,0.002152396,0.004251775,0.00002986263,0.002916822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003229002,"threshold_uncertainty_score":0.01707685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08095543779498418,"score_gpt":0.3160820625064349,"score_spread":0.2351266247114508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}