{"id":"W2082047060","doi":"10.1074/jbc.m602673200","title":"Magnesium, Essential for Base Excision Repair Enzymes, Inhibits Substrate Binding of N-Methylpurine-DNA Glycosylase","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute","keywords":"DNA glycosylase; AP site; AP endonuclease; Base excision repair; Chemistry; DNA repair; Biochemistry; DNA; Nucleotide excision repair; Endonuclease; DNA damage","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006685059,0.0002437169,0.0003920897,0.00004547675,0.00005792313,0.0000171202,0.000294862,0.0004341133,0.00008197188],"category_scores_gemma":[0.0004103365,0.0001882649,0.0005580249,0.0001138282,0.0001201771,0.000009162448,0.0001174226,0.0001778196,0.000001717812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002871556,"about_ca_system_score_gemma":0.0001094329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003342953,"about_ca_topic_score_gemma":0.000001179631,"domain_scores_codex":[0.9982086,0.00005843069,0.0008395257,0.0003474551,0.0002288617,0.000317101],"domain_scores_gemma":[0.9985069,0.00006978665,0.0006917219,0.0002783315,0.0003157024,0.0001375794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007271816,0.0002504475,0.0005689008,0.0001194831,0.00003712734,0.00004149811,0.000002448978,0.00002666679,0.9968869,0.00003802158,0.001066517,0.0002347808],"study_design_scores_gemma":[0.001287349,0.0007368,0.0002435589,0.00004028138,0.0000455574,0.0002089533,0.00003760377,0.00002919087,0.9948087,0.00036871,0.001978493,0.0002148307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970781,0.0008521022,0.001340058,0.00005805646,0.0001541246,0.0001408731,0.00006930101,0.00001918938,0.0002882004],"genre_scores_gemma":[0.9928218,0.00007474535,0.005633889,0.0000281308,0.0008496774,0.000007721987,0.0001190231,0.0000217763,0.0004432965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004293831,"threshold_uncertainty_score":0.767722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01240229235790931,"score_gpt":0.2452121198113593,"score_spread":0.23280982745345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}