{"id":"W2082050404","doi":"10.1182/blood-2006-01-010363","title":"Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis","year":2006,"lang":"en","type":"article","venue":"Blood","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences","keywords":"Chemotaxis; RAC1; Myosin; Cell biology; Motility; Biology; Actin; Chemistry; Signal transduction; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001159628,0.0002829767,0.0001224634,0.0002859634,0.0003299743,0.000381029,0.0001579296,0.0002297278,0.0009995727],"category_scores_gemma":[0.0001409384,0.0001613741,0.0001272621,0.00009211635,0.0002207496,0.0001806462,0.0002440484,0.0004301358,0.0004515602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000389369,"about_ca_system_score_gemma":0.0002505102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007151929,"about_ca_topic_score_gemma":0.001354833,"domain_scores_codex":[0.9998548,0.00001871393,0.000004454029,0.00001764185,0.00004476734,0.00005957505],"domain_scores_gemma":[0.9999378,0.000005917293,0.00001956608,0.000005015394,0.00001070725,0.00002105692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008136453,0.00001330863,0.0003224985,0.00001582106,0.000001161303,0.00007726511,0.00001364588,0.00007911069,0.9967595,0.0005200235,0.00008455031,0.002031713],"study_design_scores_gemma":[0.00002695307,0.0001709798,0.02046765,0.00001468564,0.00001493142,0.0005622832,0.00005493677,0.002876644,0.9694316,0.0005550206,0.005814231,0.00001013177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884716,0.002671293,0.004224039,0.0003016147,0.0000422775,0.00002359227,0.0001001402,0.0001184888,0.004046934],"genre_scores_gemma":[0.9948606,0.001208131,0.001477499,0.00006319268,0.00001799041,0.00001386005,0.0001114669,0.00001423379,0.002232956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009995727,"threshold_uncertainty_score":0.00334388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005875782603451759,"score_gpt":0.219305739604131,"score_spread":0.2134299570006792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}