{"id":"W2082064915","doi":"10.1161/01.atv.0000058860.62870.6e","title":"Activation of Peroxisome Proliferator–Activated Receptor Gamma and Retinoid X Receptor Results in Net Depletion of Cellular Cholesteryl Esters in Macrophages Exposed to Oxidized Lipoproteins","year":2003,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Ciglitazone; Retinoid X receptor; CD36; Scavenger receptor; Chemistry; Peroxisome proliferator-activated receptor; Cholesteryl ester; Foam cell; Receptor; Cholesterol; Nuclear receptor; Endocrinology; Biochemistry; Internal medicine; Lipoprotein; Transcription factor; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003439006,0.0004316961,0.0003840431,0.0003711706,0.0001659663,0.0002482455,0.0001789286,0.0003019768,0.001754568],"category_scores_gemma":[0.0001132848,0.0002427549,0.000335253,0.000212863,0.0003262093,0.0001936591,0.0002775217,0.0005231607,0.0009673439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002210563,"about_ca_system_score_gemma":0.0001967079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000360891,"about_ca_topic_score_gemma":0.0004928946,"domain_scores_codex":[0.9996789,0.00005887803,0.00004618596,0.00005533443,0.0000747576,0.00008598952],"domain_scores_gemma":[0.9998288,0.00002520731,0.00003924132,0.00002858106,0.00002525526,0.00005293698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003063614,0.00002382353,0.0002034893,0.00002709738,0.000004096168,0.00005977161,0.00001116614,0.000005702454,0.9989961,0.00001401983,0.0000091136,0.0003393185],"study_design_scores_gemma":[0.00003232491,0.0004558358,0.006811605,0.000007193517,0.00002027931,0.0002987478,0.00003506531,0.0001249939,0.9913939,0.0000191975,0.0007981604,0.000002598756],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949438,0.002083404,0.001403856,0.0001002737,0.00004756187,0.0000252737,0.0003005252,0.00004987503,0.001045404],"genre_scores_gemma":[0.9875972,0.001904457,0.002473961,0.000104044,0.00003339027,0.0001256979,0.0009181731,0.00002904031,0.006814043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001754568,"threshold_uncertainty_score":0.005869687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01867717611529981,"score_gpt":0.2486585658388144,"score_spread":0.2299813897235146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}