{"id":"W2082067798","doi":"10.1038/sj.bjc.6602902","title":"mTOR signaling: implications for cancer and anticancer therapy","year":2005,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":234,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Cancer Institute; Canadian Institutes of Health Research; Cancer Research Society; McGill University; Howard Hughes Medical Institute","keywords":"PI3K/AKT/mTOR pathway; EIF4E; Carcinogenesis; Translation (biology); Cancer research; Biology; RPTOR; Sirolimus; Signal transduction; Cancer; Cell biology; Genetics; Gene; Messenger RNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00148866,0.0007081513,0.001343735,0.001257495,0.0005274246,0.002203006,0.0009187922,0.00294072,0.006136007],"category_scores_gemma":[0.0008267565,0.0002167874,0.000355472,0.001190517,0.002705265,0.002734347,0.000965175,0.003285146,0.002023948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002814526,"about_ca_system_score_gemma":0.001635323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009132482,"about_ca_topic_score_gemma":0.001479764,"domain_scores_codex":[0.9997173,0.00008296036,0.00002104068,0.00004351866,0.0000735068,0.0000615869],"domain_scores_gemma":[0.9995645,0.0001431548,0.00005216115,0.00001903017,0.00009508347,0.0001261012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000807458,0.0002545248,0.0009396506,0.003322269,0.00008531938,0.001051348,0.000199155,0.002365786,0.009128035,0.2134521,0.1332185,0.6351759],"study_design_scores_gemma":[0.00009304989,0.0003684212,0.001668365,0.001066014,0.00006069319,0.001702602,0.0004079702,0.00109105,0.002281952,0.1763699,0.8148344,0.00005551666],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001704425,0.9314901,0.001218476,0.05308751,0.001842266,0.000009509274,0.00008557024,0.00006313196,0.01049893],"genre_scores_gemma":[0.03313841,0.9483086,0.001691055,0.006576403,0.004296395,0.00003527557,0.00008111574,0.00001948988,0.00585334],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006136007,"threshold_uncertainty_score":0.02052695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02103277796690395,"score_gpt":0.3267986203172294,"score_spread":0.3057658423503255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}