{"id":"W2082084049","doi":"10.1182/blood-2006-03-009720","title":"Cytotoxic CD4+ T cells use granulysin to kill Cryptococcus neoformans, and activation of this pathway is defective in HIV patients","year":2006,"lang":"en","type":"article","venue":"Blood","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Canadian Foundation for AIDS Research","keywords":"Granulysin; Perforin; Cytotoxic T cell; Cryptococcus neoformans; Biology; Degranulation; CD8; Interleukin 21; Immunology; Effector; Microbiology; Immune system; In vitro; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000109655,0.0003168771,0.0002300454,0.0002947918,0.0002531054,0.0003874268,0.0001966244,0.000301946,0.003250468],"category_scores_gemma":[0.000256623,0.0001286574,0.0001767596,0.0002119759,0.0002030259,0.0001682522,0.0001992298,0.0004265487,0.0003270728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002852804,"about_ca_system_score_gemma":0.0001896948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00101517,"about_ca_topic_score_gemma":0.0005727155,"domain_scores_codex":[0.9998956,0.00001773261,0.0000120701,0.00002512829,0.00001641731,0.00003311416],"domain_scores_gemma":[0.9998999,0.00001647628,0.00002914045,0.00001017314,0.00001344631,0.00003093429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00392856,0.0005228103,0.2996626,0.0005783468,0.0001794802,0.01256644,0.0006010943,0.0006378586,0.5216916,0.001066712,0.003907136,0.1546573],"study_design_scores_gemma":[0.000461791,0.003472249,0.7155679,0.0002427395,0.0004918145,0.07668521,0.0007372829,0.002850526,0.1709622,0.001179727,0.02730089,0.00004766186],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945209,0.002152391,0.000479879,0.0001463529,0.00002814323,0.00003609935,0.0001971908,0.00008432535,0.002354796],"genre_scores_gemma":[0.9973032,0.0004338876,0.0002976735,0.00012341,0.00001507497,0.0000193025,0.0002168878,0.000005185437,0.001585299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003250468,"threshold_uncertainty_score":0.01087391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00862211803470153,"score_gpt":0.2169350165373099,"score_spread":0.2083128985026084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}