{"id":"W2082104199","doi":"10.1039/b711869d","title":"The design, synthesis, and characterization of the first cavitand-based de novo hetero-template-assembled synthetic proteins (Hetero-TASPs)","year":2007,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Cavitand; Linker; Monomer; Peptide; Guanidine; Helix (gastropod); Amide; Combinatorial chemistry; Helix bundle; Stereochemistry; Protein structure; Supramolecular chemistry; Biochemistry; Molecule; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005713358,0.0002716535,0.0002372902,0.00001837583,0.0002923127,0.0000630975,0.0004622225,0.0002738939,0.00003576802],"category_scores_gemma":[0.0003326844,0.0001860722,0.0002143195,0.0002335072,0.0001926154,0.000004637297,0.0001518378,0.0001224467,0.000002185184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005576418,"about_ca_system_score_gemma":0.0001027477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000106602,"about_ca_topic_score_gemma":0.00001563969,"domain_scores_codex":[0.9984382,0.00007253913,0.0003946421,0.0004404605,0.0002457663,0.0004083726],"domain_scores_gemma":[0.9987416,0.00009229459,0.0002528906,0.0007053945,0.00008808498,0.0001197167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008135314,0.00008068573,0.0008285847,0.00008507729,0.0001049708,0.000006322499,0.00001191802,8.223184e-7,0.9981869,0.000001430004,0.00001421222,0.0005977094],"study_design_scores_gemma":[0.0002704919,0.00002834971,0.0009383875,0.00009050223,0.0001205708,0.00004368337,0.00001756493,0.00007095566,0.9964988,0.00001085987,0.001679216,0.0002305941],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.91989,0.0003408449,0.07888162,0.000511884,0.0000266457,0.0002477097,0.00001724298,0.00001552372,0.00006855987],"genre_scores_gemma":[0.9992874,0.0001017481,0.0002274343,0.0001441531,0.00006739185,0.0000341407,0.0000237992,0.00004657386,0.0000673858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0793974,"threshold_uncertainty_score":0.7587804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004943043212347732,"score_gpt":0.1998834119303065,"score_spread":0.1949403687179587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}