{"id":"W2082104199","doi":"10.1039/b711869d","title":"The design, synthesis, and characterization of the first cavitand-based de novo hetero-template-assembled synthetic proteins (Hetero-TASPs)","year":2007,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Cavitand; Linker; Monomer; Peptide; Guanidine; Helix (gastropod); Amide; Combinatorial chemistry; Helix bundle; Stereochemistry; Protein structure; Supramolecular chemistry; Biochemistry; Molecule; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002279359,0.0002666921,0.0002456623,0.0001017167,0.0001194747,0.0002497592,0.0002732377,0.0002951687,0.0003175769],"category_scores_gemma":[0.0003464696,0.0001301847,0.0001671912,0.0001280176,0.0002400835,0.0002476625,0.0001463121,0.000403098,0.0002744104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003579374,"about_ca_system_score_gemma":0.0002483281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003118377,"about_ca_topic_score_gemma":0.0004171656,"domain_scores_codex":[0.999878,0.00002127438,0.00001057006,0.00003441298,0.00004004971,0.00001553406],"domain_scores_gemma":[0.999775,0.00004340743,0.00006965941,0.00002425876,0.00004820415,0.0000395955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002807426,0.00001367855,0.0001915409,0.0000389667,0.000003830173,0.00003621042,0.00001878225,0.0003388031,0.9960277,0.0001292277,0.0000312142,0.003142097],"study_design_scores_gemma":[0.000005159743,0.0001130389,0.0006812593,0.000001938602,0.00000510771,0.0001659618,0.000009975759,0.001506649,0.9955732,0.00003673019,0.001898116,0.000002870989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9464507,0.001201188,0.05037795,0.0001016701,0.00002684747,0.0001446727,0.0002685614,0.0002022255,0.001226134],"genre_scores_gemma":[0.9122472,0.0009556498,0.08308177,0.00008418861,0.00001749115,0.000149488,0.0008203985,0.00008384736,0.002559899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003579374,"threshold_uncertainty_score":0.002597034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004943043212347732,"score_gpt":0.1998834119303065,"score_spread":0.1949403687179587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}