{"id":"W2082127519","doi":"10.1111/j.1600-6143.2007.02118.x","title":"Interferon-γ and Donor MHC Class I Control Alternative Macrophage Activation and Activin Expression in Rejecting Kidney Allografts: A Shift in the Th1-Th2 Paradigm","year":2008,"lang":"en","type":"article","venue":"American Journal of Transplantation","topic":"Organ Transplantation Techniques and Outcomes","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Genome Alberta; Astellas Pharma; University of Alberta; Roche Organ Transplant Research Foundation; Kidney Foundation of Canada; Genome Canada","keywords":"Medicine; Immunology; Major histocompatibility complex; MHC class II; CD74; Interferon; Kidney; MHC class I; Immune system; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002251371,0.0002739143,0.0002333431,0.0002294572,0.0001092511,0.0004319246,0.000117417,0.0002444604,0.0005697267],"category_scores_gemma":[0.0001443391,0.0001352213,0.0002077355,0.0001490666,0.00025445,0.0002554181,0.0001807353,0.0004573103,0.0001983144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00021329,"about_ca_system_score_gemma":0.0001863059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000154862,"about_ca_topic_score_gemma":0.0002395249,"domain_scores_codex":[0.999826,0.00001940452,0.0000183754,0.00004982078,0.00003924518,0.00004718512],"domain_scores_gemma":[0.9998753,0.0000158177,0.00004641309,0.00001225359,0.00001389905,0.00003626661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001126416,0.000007372653,0.0009968614,0.00001314826,0.000001833194,0.00001640991,0.0000234598,0.00001964764,0.9981963,0.00004708719,0.000004767421,0.0005604044],"study_design_scores_gemma":[0.00003083305,0.0003445387,0.06960957,0.00001566379,0.00004444344,0.0003727946,0.0002263247,0.001363856,0.9259667,0.0002769626,0.001738662,0.000009705262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970924,0.0007756436,0.001478175,0.00003294376,0.00001404278,0.000007319974,0.00009619672,0.00002098117,0.0004823136],"genre_scores_gemma":[0.997235,0.0004607872,0.001160762,0.00004723933,0.00001580472,0.00002489535,0.0001580188,0.00001206216,0.0008855877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005697267,"threshold_uncertainty_score":0.001905918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01062360069596761,"score_gpt":0.2660252362116977,"score_spread":0.25540163551573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}