{"id":"W2082127519","doi":"10.1111/j.1600-6143.2007.02118.x","title":"Interferon-γ and Donor MHC Class I Control Alternative Macrophage Activation and Activin Expression in Rejecting Kidney Allografts: A Shift in the Th1-Th2 Paradigm","year":2008,"lang":"en","type":"article","venue":"American Journal of Transplantation","topic":"Organ Transplantation Techniques and Outcomes","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Genome Alberta; Astellas Pharma; University of Alberta; Roche Organ Transplant Research Foundation; Kidney Foundation of Canada; Genome Canada","keywords":"Medicine; Immunology; Major histocompatibility complex; MHC class II; CD74; Interferon; Kidney; MHC class I; Immune system; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003712246,0.0001357401,0.0003254422,0.0002933947,0.00005814488,0.00001919661,0.00007244373,0.00004324922,0.000006728935],"category_scores_gemma":[0.0000371595,0.00009396322,0.00004714284,0.000204179,0.0001456977,0.0003244594,0.000002765577,0.0003724927,2.861814e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005224789,"about_ca_system_score_gemma":0.00005569673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002203265,"about_ca_topic_score_gemma":0.00004009273,"domain_scores_codex":[0.9988378,0.0002250735,0.0004269707,0.0001459466,0.00021729,0.0001468762],"domain_scores_gemma":[0.9991584,0.0003284067,0.0003294894,0.00006966213,0.00002983824,0.00008424263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01266493,0.0004017281,0.8155431,0.0005649619,0.0001360859,0.001420917,0.0815249,0.00008313644,0.07438666,0.0001341205,0.00009297406,0.01304649],"study_design_scores_gemma":[0.006509775,0.001646777,0.9495884,0.00108348,0.0001251037,0.002045146,0.002507461,0.0002072549,0.03585435,0.0002024361,0.00006729155,0.0001624956],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758425,0.00006478446,0.02107637,0.002627857,0.00003675544,0.0002722048,0.0000119828,0.00001032451,0.00005720773],"genre_scores_gemma":[0.9935514,0.004243593,0.001088231,0.001033946,0.00004680031,0.000009259216,0.00001023021,0.00001266805,0.000003889297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1340453,"threshold_uncertainty_score":0.3831709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01062360069596761,"score_gpt":0.2660252362116977,"score_spread":0.25540163551573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}