{"id":"W2082150533","doi":"10.1073/pnas.1009845107","title":"Pathway analysis of <i>Candida albicans</i> survival and virulence determinants in a murine infection model","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"Genome Canada","keywords":"Virulence; Biology; Candida albicans; Gene; Ergosterol; Microbiology; Transcriptome; Corpus albicans; Doxycycline; Context (archaeology); Mutant; Tetracycline; Phenotype; Genetics; Antibiotics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001796655,0.0004595223,0.0003530237,0.0006160511,0.0002321421,0.0005265639,0.0002358217,0.000281331,0.001655125],"category_scores_gemma":[0.00009034033,0.0001316613,0.0005676608,0.0005561697,0.0001673204,0.000263009,0.0002170114,0.0006805333,0.0004036739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004089671,"about_ca_system_score_gemma":0.0004666421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001140255,"about_ca_topic_score_gemma":0.001447079,"domain_scores_codex":[0.9998116,0.00001674528,0.00001287323,0.00004910618,0.00006181403,0.00004784757],"domain_scores_gemma":[0.9998767,0.00001038702,0.00004174796,0.000009552209,0.0000300307,0.00003156602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001863298,0.00003548988,0.0005492098,0.0001271744,0.0000128874,0.00004258985,0.0000107187,0.0002622947,0.9963528,0.0001332332,0.0001093079,0.002177856],"study_design_scores_gemma":[0.00003391956,0.0005756679,0.02510318,0.00003443722,0.000108622,0.0003208581,0.0001111861,0.006144054,0.961273,0.0003010139,0.005971898,0.0000221313],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9603428,0.002686804,0.01999681,0.0003364515,0.00007568039,0.0001825806,0.01119351,0.0007171782,0.004468068],"genre_scores_gemma":[0.9616648,0.003702,0.02032788,0.0002185631,0.00001253926,0.0003089565,0.008292024,0.0001285196,0.005344768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001655125,"threshold_uncertainty_score":0.005536973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03412700082166779,"score_gpt":0.3278667806593463,"score_spread":0.2937397798376785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}