{"id":"W2082181174","doi":"10.1210/jc.2004-0376","title":"Congenital Leptin Deficiency Due to Homozygosity for the Δ133G Mutation: Report of Another Case and Evaluation of Response to Four Years of Leptin Therapy","year":2004,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":276,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital","funders":"Health Research Board; Wellcome Trust","keywords":"Leptin; Missense mutation; Internal medicine; Medicine; Endocrinology; Frameshift mutation; Hyperinsulinemia; Mutation; Obesity; Biology; Genetics; Gene; Insulin resistance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000247201,0.001100187,0.0008843645,0.001514652,0.00193355,0.0006248945,0.0008889007,0.00251006,0.001144285],"category_scores_gemma":[0.002225171,0.0004997874,0.0008728498,0.0007894242,0.00140252,0.0004096206,0.0006162085,0.001601439,0.0003161869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001990802,"about_ca_system_score_gemma":0.001739409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.04403041,"about_ca_topic_score_gemma":0.0332003,"domain_scores_codex":[0.9995989,0.00002950162,0.00003629993,0.00008014181,0.00008327169,0.0001717644],"domain_scores_gemma":[0.9989236,0.0003020771,0.0001879084,0.00006600655,0.0001114002,0.0004090183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00006707367,0.00007402454,0.01115405,0.00001709371,0.00001227962,0.9827885,0.0005540831,0.00006879563,0.002948877,0.0001133011,0.0001445522,0.00205741],"study_design_scores_gemma":[0.00003008974,0.0002374238,0.02131977,0.00001000023,0.00002923002,0.9759477,0.0002444782,0.0002046233,0.001148269,0.00004644749,0.0007606738,0.00002135787],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99506,0.0008776228,0.0006525858,0.0007404674,0.00007437531,0.00004091775,0.0000939122,0.00006744145,0.002392709],"genre_scores_gemma":[0.997139,0.0004954303,0.0006766336,0.0002856375,0.00007800113,0.00001309197,0.00008449124,0.00001724352,0.001210589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04403041,"threshold_uncertainty_score":0.0875482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1403618685461349,"score_gpt":0.4148122683175677,"score_spread":0.2744503997714327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}