{"id":"W2082196865","doi":"10.1016/j.neuint.2008.09.014","title":"FTDP-17 missense mutations site-specifically inhibit as well as promote dephosphorylation of microtubule-associated protein tau by protein phosphatases of HEK-293 cell extract","year":2008,"lang":"en","type":"article","venue":"Neurochemistry International","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Dephosphorylation; Phosphorylation; Phosphatase; Protein phosphatase 2; Biology; Kinase; Okadaic acid; Transfection; Cell biology; Molecular biology; Chemistry; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00008750783,0.0002689682,0.0003157365,0.00008781841,0.00009660457,0.00001898378,0.00019385,0.0001543391,0.002018894],"category_scores_gemma":[0.0004834086,0.000271299,0.0001944564,0.0002170825,0.0002216435,0.0001337711,0.00005817016,0.0002917238,0.0001815449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001402056,"about_ca_system_score_gemma":0.0005174165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001463993,"about_ca_topic_score_gemma":0.000002415258,"domain_scores_codex":[0.9975659,0.00004550282,0.0006064943,0.0004591867,0.0010264,0.0002964739],"domain_scores_gemma":[0.9981543,0.00007762367,0.0004471873,0.0003033089,0.0007198721,0.0002976608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001218408,0.003682348,0.003292848,0.0001327386,0.0007047837,0.0006879303,0.00009044073,0.000006970335,0.9859737,0.00000835449,0.004074198,0.000127295],"study_design_scores_gemma":[0.003430632,0.0004349949,0.003160131,0.0002492793,0.0001085356,0.0001517158,0.00003698787,0.0001102487,0.9907858,0.00006671849,0.001292298,0.0001726342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910479,0.0008309686,0.0000156733,0.0003697572,0.00002614706,0.001135179,0.0008397003,0.00005104632,0.005683633],"genre_scores_gemma":[0.9912899,0.00006432408,0.0003802555,0.00005304208,0.00004849645,0.0001286381,0.003282859,0.00004005923,0.004712468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004812141,"threshold_uncertainty_score":0.9999739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0138876582145512,"score_gpt":0.2694815630793781,"score_spread":0.2555939048648269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}