{"id":"W2082201244","doi":"10.1021/cb100008p","title":"Targeted Delivery of Antigen Processing Inhibitors to Antigen Presenting Cells <i>via</i> Mannose Receptors","year":2010,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Biotechnology and Biological Sciences Research Council; Rheinische Friedrich-Wilhelms-Universität Bonn; Wellcome Trust","keywords":"Pepstatin; Cell biology; Biology; Endocytic cycle; Epitope; Endocytosis; Mannose; Biochemistry; Antigen-presenting cell; Antigen; Receptor; In vitro; Cytotoxic T cell; Enzyme; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001686198,0.0003376788,0.0003206872,0.00008489277,0.00008500479,0.0003315943,0.0002241912,0.0003080184,0.0004129638],"category_scores_gemma":[0.0001199818,0.0000796686,0.0002193425,0.00006424807,0.0001612223,0.0002454364,0.0001240089,0.0004111467,0.0002124903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002839992,"about_ca_system_score_gemma":0.000124386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002615527,"about_ca_topic_score_gemma":0.0002457492,"domain_scores_codex":[0.9998751,0.00002571268,0.000009114967,0.00002844348,0.00002993586,0.00003172622],"domain_scores_gemma":[0.9999057,0.00002324481,0.00003913428,0.000009087445,0.00000968378,0.00001321351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003958359,0.00001143857,0.00004996028,0.00003239718,0.000003768962,0.00001973183,0.000005026924,0.0001603892,0.9986005,0.00009194388,0.00001020917,0.0009748619],"study_design_scores_gemma":[0.000004419006,0.0001730714,0.0002121947,0.00000137706,0.0000071799,0.00008213309,0.000002436609,0.0005536991,0.9977175,0.0000126707,0.00123137,0.000002024635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9641685,0.004771102,0.0292545,0.0001183029,0.00002934003,0.00008657961,0.0001567934,0.0001286084,0.001286287],"genre_scores_gemma":[0.9780335,0.002645787,0.017294,0.00006751845,0.00001955611,0.00004031045,0.0001422346,0.00003010916,0.001726967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004129638,"threshold_uncertainty_score":0.002060592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01354331552311865,"score_gpt":0.2940789143329599,"score_spread":0.2805355988098412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}