{"id":"W2082213986","doi":"10.1093/neuonc/nou310","title":"Druggable targets in pediatric neurocutaneous melanocytosis: Molecular and drug sensitivity studies in xenograft and ex vivo tumor cell culture to identify agents for therapy","year":2014,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cutaneous Melanoma Detection and Management","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary; University of Lethbridge; Calgary Laboratory Services","funders":"Alberta Children's Hospital Foundation; Children's Hospital Foundation","keywords":"Druggability; Neuroblastoma RAS viral oncogene homolog; Cancer research; In vivo; In vitro; Cell culture; Medicine; Leptomeninges; Ex vivo; Drug discovery; Biology; Bioinformatics; Gene; Mutation; Genetics; Internal medicine; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004259363,0.000247771,0.0005786674,0.0003607788,0.00007190429,0.00002385059,0.00005935139,0.00009160043,0.000007816638],"category_scores_gemma":[0.0002716568,0.0002254281,0.00005765479,0.0002740484,0.00005784703,0.00004316786,0.0001353337,0.0002538087,0.00000827253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001054653,"about_ca_system_score_gemma":0.00003167881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000517668,"about_ca_topic_score_gemma":0.0003554822,"domain_scores_codex":[0.9981971,0.0003325811,0.0003296701,0.0005861965,0.000165326,0.0003890842],"domain_scores_gemma":[0.9990875,0.0003617684,0.0001051963,0.0002033981,0.00007161629,0.0001705129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002110104,0.0009116411,0.01233767,0.000809929,0.00008282519,0.01081792,0.008112875,0.0002637557,0.9351875,0.00004542924,0.01677156,0.01254878],"study_design_scores_gemma":[0.0201009,0.01095231,0.01545591,0.0001147585,0.0005279665,0.006359822,0.004752015,0.002853594,0.1677743,0.0005008019,0.7693646,0.001243026],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994264,0.001234494,0.000105443,0.001571236,0.000487768,0.001558035,0.0000056566,0.00005674205,0.0007166278],"genre_scores_gemma":[0.9911122,0.001888689,0.0003860762,0.006013894,0.0001361047,0.0001174175,0.000003029926,0.00003626395,0.0003063366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7674131,"threshold_uncertainty_score":0.9192693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02157681325720592,"score_gpt":0.3181087935690841,"score_spread":0.2965319803118782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}