{"id":"W2082213986","doi":"10.1093/neuonc/nou310","title":"Druggable targets in pediatric neurocutaneous melanocytosis: Molecular and drug sensitivity studies in xenograft and ex vivo tumor cell culture to identify agents for therapy","year":2014,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cutaneous Melanoma Detection and Management","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary; University of Lethbridge; Calgary Laboratory Services","funders":"Alberta Children's Hospital Foundation; Children's Hospital Foundation","keywords":"Druggability; Neuroblastoma RAS viral oncogene homolog; Cancer research; In vivo; In vitro; Cell culture; Medicine; Leptomeninges; Ex vivo; Drug discovery; Biology; Bioinformatics; Gene; Mutation; Genetics; Internal medicine; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004915405,0.0003656078,0.000486115,0.000335759,0.0001720112,0.0002590182,0.0003063733,0.0002888751,0.001553949],"category_scores_gemma":[0.0002124127,0.0001219292,0.0002638026,0.0002841918,0.0001798926,0.0003228499,0.0001311557,0.0007658614,0.0004464643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000354042,"about_ca_system_score_gemma":0.0002287279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009034106,"about_ca_topic_score_gemma":0.00139927,"domain_scores_codex":[0.9998066,0.00006419609,0.00002373163,0.00003285712,0.00004805833,0.00002465827],"domain_scores_gemma":[0.9997382,0.0001135328,0.0000399853,0.00005172702,0.00002905807,0.00002746373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002372607,0.0005052395,0.0009504575,0.0001193925,0.00001524066,0.0001328952,0.00006604003,0.0007200586,0.9931188,0.0001560874,0.0001406125,0.0038379],"study_design_scores_gemma":[0.00003511582,0.002861104,0.004161903,0.000009372363,0.00003539535,0.0006373146,0.00003921684,0.001723222,0.9879408,0.00003161794,0.00251988,0.000005082512],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877141,0.004116363,0.005171161,0.0001085899,0.00002994181,0.0001973794,0.000891016,0.00007575745,0.001695703],"genre_scores_gemma":[0.9816828,0.004011459,0.01104797,0.00004041871,0.00001666804,0.0002002629,0.001415163,0.00003355024,0.00155177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001553949,"threshold_uncertainty_score":0.005198479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02157681325720592,"score_gpt":0.3181087935690841,"score_spread":0.2965319803118782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}