{"id":"W2082219573","doi":"10.1074/jbc.275.20.15034","title":"Physical Interactions between Phospholamban and Sarco(endo)plasmic Reticulum Ca2+-ATPases Are Dissociated by Elevated Ca2+, but Not by Phospholamban Phosphorylation, Vanadate, or Thapsigargin, and Are Enhanced by ATP","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Medical Research Council; Medical Research Council Canada; Heart and Stroke Foundation of Canada","keywords":"Phospholamban; SERCA; Thapsigargin; Phosphorylation; Endoplasmic reticulum; Chemistry; Vanadate; ATPase; Biophysics; Biochemistry; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004851556,0.0008292047,0.0006175858,0.0002675325,0.0003902437,0.000723185,0.0005568909,0.0004056378,0.001358558],"category_scores_gemma":[0.0003398162,0.0006202405,0.0006806795,0.0001966764,0.0006471145,0.0006045509,0.0007067642,0.001254195,0.0006599699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004617302,"about_ca_system_score_gemma":0.0003628034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004488901,"about_ca_topic_score_gemma":0.0009534549,"domain_scores_codex":[0.9992086,0.0001135612,0.000117341,0.0001561242,0.000235094,0.0001692616],"domain_scores_gemma":[0.9995645,0.00006688407,0.0001309277,0.00005716246,0.00004275684,0.0001377146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001332524,0.00004039066,0.0001250602,0.00004273691,0.00001356897,0.00007364267,0.00001630773,0.00001589427,0.9991544,0.00005774202,0.00002234269,0.0003045722],"study_design_scores_gemma":[0.00006634444,0.0001828113,0.009620788,0.00001172217,0.00003044651,0.0004983617,0.00003437485,0.0005243695,0.9869931,0.00007484481,0.001951985,0.00001080717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923375,0.003328126,0.002252286,0.0002000793,0.00008069476,0.00004056845,0.0002023766,0.00005283312,0.001505586],"genre_scores_gemma":[0.9903995,0.001563276,0.00306175,0.0001997004,0.00003671617,0.000106457,0.001138507,0.00004607274,0.003447909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001358558,"threshold_uncertainty_score":0.004544854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01149896967484414,"score_gpt":0.2416778661059641,"score_spread":0.2301788964311199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}