{"id":"W2082222989","doi":"10.1258/0004563041201455","title":"Thiopurine methyltransferase: should it be measured before commencing thiopurine drug therapy?","year":2004,"lang":"en","type":"review","venue":"Annals of Clinical Biochemistry International Journal of Laboratory Medicine","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"","keywords":"Thiopurine methyltransferase; Azathioprine; Pharmacogenetics; Medicine; Mercaptopurine; Xanthine oxidase; Pharmacology; Hypoxanthine Phosphoribosyltransferase; Methyltransferase; Population; Allopurinol; Adverse effect; Hypoxanthine-guanine phosphoribosyltransferase; Internal medicine; Biology; Enzyme; Genetics; Genotype; Methylation; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.008882105,0.0009071365,0.005832267,0.0006522281,0.00006284904,0.00003129398,0.002022725,0.00105104,0.0009123472],"category_scores_gemma":[0.01253227,0.0005957266,0.001955085,0.0008428806,0.001136294,0.0001965987,0.0002083117,0.003520234,0.00001251285],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005248087,"about_ca_system_score_gemma":0.01048212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003707727,"about_ca_topic_score_gemma":0.000003377668,"domain_scores_codex":[0.9865321,0.000618909,0.006965569,0.0007012571,0.004605419,0.0005767491],"domain_scores_gemma":[0.9826892,0.002548085,0.004014546,0.0009381542,0.008731584,0.001078434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006099185,0.004108079,0.0003281052,0.03301074,0.02432237,0.006830354,0.0007693031,0.000007291266,0.002079944,0.0001704863,0.1615007,0.7607734],"study_design_scores_gemma":[0.009498748,0.002025033,0.00003093716,0.07560762,0.00160865,0.001095622,0.000193661,0.000003985369,0.009335777,0.0001071196,0.9000389,0.0004539698],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002475533,0.9466704,0.00006679486,0.04739764,0.001719379,0.0005932458,0.0004181707,0.00003334303,0.0006254539],"genre_scores_gemma":[0.005255754,0.9814817,0.0004721657,0.00583032,0.00607424,0.00001681815,0.0003439214,0.0001274744,0.0003975561],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7603195,"threshold_uncertainty_score":0.9996494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2797859895613061,"score_gpt":0.5287442597243529,"score_spread":0.2489582701630468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}