{"id":"W2082229346","doi":"10.1006/jmbi.2001.4811","title":"A novel mode of regulation of an RNA-cleaving DNAzyme by effectors that bind to both enzyme and substrate","year":2001,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Ribozyme; Deoxyribozyme; RNA; Ligase ribozyme; Effector; DNA; Biochemistry; Nucleic acid; Biology; Enzyme; Regulator; Chemistry; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004958121,0.0004749813,0.0005026353,0.0002703263,0.0002752019,0.001032875,0.001037827,0.0008462894,0.001917275],"category_scores_gemma":[0.0004990922,0.0004068243,0.0003817023,0.0001210065,0.0005935746,0.0007706974,0.0004291432,0.001098276,0.0007501499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003561222,"about_ca_system_score_gemma":0.0001514651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000108693,"about_ca_topic_score_gemma":0.0001931036,"domain_scores_codex":[0.9996037,0.00004344086,0.00001956967,0.0001573503,0.0001128129,0.00006312205],"domain_scores_gemma":[0.9995783,0.0001493042,0.00004979737,0.0000976137,0.00005144317,0.00007354277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009637338,0.0000286676,0.0001180581,0.00002404762,0.000003667962,0.000104637,0.00002260979,0.00006468636,0.995555,0.001508006,0.0001014966,0.002372817],"study_design_scores_gemma":[0.00002866123,0.0001416073,0.0008921598,0.000003908643,0.000006186508,0.0004210081,0.00001490523,0.004647603,0.9918184,0.0005696283,0.0014461,0.000009872559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.803951,0.00236498,0.1802552,0.0008899719,0.000611403,0.0001498739,0.0001944605,0.002463317,0.009119659],"genre_scores_gemma":[0.975041,0.000250212,0.01849058,0.0002446796,0.00005967323,0.00008412474,0.0001044037,0.00008764841,0.005637744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001917275,"threshold_uncertainty_score":0.006413937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008456663279976831,"score_gpt":0.2861808668107881,"score_spread":0.2777242035308112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}