{"id":"W2082235998","doi":"10.1042/bj20030287","title":"Human recombinant endopeptidase PHEX has a strict S1' specificity for acidic residues and cleaves peptides derived from fibroblast growth factor-23 and matrix extracellular phosphoglycoprotein","year":2003,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Parathyroid Disorders and Treatments","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"PHEX; Biochemistry; Endopeptidase; Peptide; Chemistry; Biology; Amino acid; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001489198,0.0005315099,0.0003444753,0.00009490041,0.00009546051,0.0001962504,0.0001675754,0.0002147202,0.0007632225],"category_scores_gemma":[0.0001459703,0.0001177416,0.0001759012,0.0002034464,0.00020541,0.0001331932,0.0001750941,0.0003147094,0.0004446952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002299439,"about_ca_system_score_gemma":0.0001773248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003427336,"about_ca_topic_score_gemma":0.0005151419,"domain_scores_codex":[0.9998541,0.00002671982,0.000008952198,0.00004206402,0.00004311158,0.00002498853],"domain_scores_gemma":[0.9998856,0.00003029004,0.00003093627,0.00001190609,0.00001472605,0.00002641029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006980998,0.00001210924,0.0001063679,0.00002706673,0.000003341,0.0000251164,0.000004836294,0.00004632129,0.9984421,0.00002845304,0.00001725833,0.001217183],"study_design_scores_gemma":[0.00001706497,0.000310113,0.001706032,0.000002814465,0.000009731211,0.0003684053,0.000007378319,0.0002774287,0.9951714,0.00001797281,0.002108061,0.000003704271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875239,0.0020726,0.008477562,0.00004641213,0.00001957725,0.00007755776,0.0003774133,0.00006294929,0.001342088],"genre_scores_gemma":[0.9809079,0.001333897,0.01096026,0.00005452424,0.00001445744,0.00005723189,0.001849891,0.00002948277,0.004792326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007632225,"threshold_uncertainty_score":0.002553165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02943102162341411,"score_gpt":0.2737695862343085,"score_spread":0.2443385646108944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}