{"id":"W2082235998","doi":"10.1042/bj20030287","title":"Human recombinant endopeptidase PHEX has a strict S1' specificity for acidic residues and cleaves peptides derived from fibroblast growth factor-23 and matrix extracellular phosphoglycoprotein","year":2003,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Parathyroid Disorders and Treatments","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"PHEX; Biochemistry; Endopeptidase; Peptide; Chemistry; Biology; Amino acid; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001384737,0.0003263105,0.0004736545,0.00008726759,0.0003767571,0.0001845331,0.00008492614,0.0001782702,0.00008671646],"category_scores_gemma":[0.0002616262,0.0002563508,0.0001507405,0.00009142305,0.0002700324,0.0001223792,0.00003874164,0.0003012043,0.00001215032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007824628,"about_ca_system_score_gemma":0.00008194969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009558844,"about_ca_topic_score_gemma":0.000007347074,"domain_scores_codex":[0.9983929,0.00007912666,0.0004385104,0.0004334086,0.0002435144,0.0004124737],"domain_scores_gemma":[0.9989635,0.0000968094,0.000201159,0.0001815467,0.0001010242,0.0004559117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005359164,0.0004195119,0.01231241,0.00003431972,0.0001734742,0.0001479927,0.0001906364,7.285412e-8,0.9802107,0.000111194,0.005633707,0.0002300594],"study_design_scores_gemma":[0.00838051,0.0008510319,0.02907174,0.0001914082,0.0001549212,0.0003616339,0.0004723714,0.00001125475,0.9569046,0.002646625,0.0006391531,0.0003146934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9765221,0.02212499,0.0003663293,0.0002312324,0.00004825406,0.0005339434,0.00007784342,0.00002837074,0.00006693697],"genre_scores_gemma":[0.9922518,0.0009032766,0.00622892,0.00002888904,0.0001283558,0.00002006892,0.0000588121,0.00003761734,0.0003423259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02330604,"threshold_uncertainty_score":0.9999889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02943102162341411,"score_gpt":0.2737695862343085,"score_spread":0.2443385646108944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}