{"id":"W2082247320","doi":"10.1089/nat.2011.0298","title":"Immunostimulatory Potential of Silencing RNAs Can Be Mediated by a Non-Uridine-Rich Toll-Like Receptor 7 Motif","year":2011,"lang":"en","type":"article","venue":"Nucleic Acid Therapeutics","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pfizer (Canada)","funders":"Bundesministerium für Bildung und Forschung","keywords":"TLR7; Small interfering RNA; Biology; Gene silencing; RNA interference; RNA; Sequence motif; Innate immune system; Cell biology; Phosphodiester bond; RNA silencing; Trans-acting siRNA; Structural motif; Toll-like receptor; Molecular biology; Biochemistry; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001915933,0.0003475497,0.0002017292,0.0001517615,0.00008970483,0.0002249095,0.0001412965,0.0002842582,0.0009116599],"category_scores_gemma":[0.0002214871,0.00008339665,0.0002092513,0.00007658712,0.0001962508,0.0001279927,0.0001456258,0.0002024477,0.0002910253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001138052,"about_ca_system_score_gemma":0.00009503408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000963046,"about_ca_topic_score_gemma":0.0001866442,"domain_scores_codex":[0.9998525,0.00004281324,0.00001219754,0.00003167484,0.00003819789,0.00002264416],"domain_scores_gemma":[0.9998624,0.00005361716,0.00003748339,0.0000122049,0.00001932135,0.0000149614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002564121,0.000003349234,0.00002689537,0.00001936299,0.000001891559,0.00001074034,0.000002794112,0.00002115526,0.9992434,0.00003282095,0.000004322306,0.0006076435],"study_design_scores_gemma":[0.000002991099,0.0001321967,0.0005275823,0.000002467288,0.00000912905,0.00005727267,0.000003220029,0.0002466261,0.9984133,0.0000169741,0.0005865401,0.000001641858],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862737,0.003592304,0.006827614,0.00005402694,0.00003103634,0.00003118055,0.0001192017,0.00007288266,0.002998132],"genre_scores_gemma":[0.9940941,0.0008869317,0.003671382,0.00005065669,0.00001204822,0.00003081128,0.0001759852,0.00001774795,0.001060291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009116599,"threshold_uncertainty_score":0.003049791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01630851021603087,"score_gpt":0.2182998908179097,"score_spread":0.2019913806018788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}