{"id":"W2082307535","doi":"10.1128/mcb.00295-06","title":"Mice with a Targeted Mutation of <i>Patched2</i> Are Viable but Develop Alopecia and Epidermal Hyperplasia","year":2006,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Cancer Institute; Hospital for Sick Children","keywords":"Biology; Patched; Sonic hedgehog; Mutation; Cancer research; Genetics; Cell biology; Pathology; Hedgehog; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000256342,0.001657778,0.0006747497,0.001661401,0.0004789239,0.0005473955,0.000911871,0.00147257,0.009269669],"category_scores_gemma":[0.0001640603,0.0006234771,0.0006701713,0.0005099319,0.0009293694,0.0004580273,0.0007202313,0.001488741,0.003769677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004929298,"about_ca_system_score_gemma":0.0002254363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006938894,"about_ca_topic_score_gemma":0.001379999,"domain_scores_codex":[0.9994529,0.00004090316,0.00005502195,0.0002104853,0.0001507713,0.00008998631],"domain_scores_gemma":[0.9994081,0.00004861124,0.0002814826,0.00004785947,0.00002333507,0.0001905861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001665875,0.00005532669,0.0003810296,0.00005560529,0.00002261563,0.0004135618,0.00003032566,0.00005083753,0.9963509,0.0003659339,0.0002874062,0.001819915],"study_design_scores_gemma":[0.0003363122,0.0006916946,0.03036147,0.00007735712,0.0001938116,0.01283388,0.0001360579,0.002382467,0.9171523,0.0005112213,0.0352571,0.00006626979],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9499515,0.002485451,0.02002179,0.0007035945,0.0002928451,0.000249964,0.01205461,0.003255605,0.01098463],"genre_scores_gemma":[0.9258263,0.001860915,0.01067647,0.000519148,0.0001439053,0.0004776352,0.01133147,0.001087562,0.04807658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009269669,"threshold_uncertainty_score":0.03101009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004804814230342976,"score_gpt":0.1935289254154894,"score_spread":0.1887241111851464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}