{"id":"W2082319347","doi":"10.1038/gt.2015.25","title":"Gene delivery to the spinal cord using MRI-guided focused ultrasound","year":2015,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":93,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Toronto Rehabilitation Institute; Sunnybrook Hospital; Sunnybrook Health Science Centre","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research","keywords":"Spinal cord; Gene delivery; Microbubbles; Genetic enhancement; Magnetic resonance imaging; Green fluorescent protein; Viral vector; Biology; Medicine; Pathology; Neuroscience; Ultrasound; Gene; Radiology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002455071,0.0004587393,0.0003632359,0.000500246,0.0002692742,0.0004164765,0.0004739343,0.0005973293,0.001088099],"category_scores_gemma":[0.0003301493,0.0002205918,0.0003146893,0.0002099173,0.0004617337,0.0004504899,0.0003218775,0.0004778268,0.0003617064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003866231,"about_ca_system_score_gemma":0.0004969778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002832701,"about_ca_topic_score_gemma":0.003565784,"domain_scores_codex":[0.9998536,0.00001977623,0.000007736307,0.00004463556,0.00004402068,0.00003021336],"domain_scores_gemma":[0.9999181,0.0000237859,0.00002654271,0.000006645664,0.00001290185,0.00001201071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009194854,0.00004279529,0.00007439845,0.0001571094,0.00001012171,0.0001200198,0.00006166237,0.0003814939,0.9895055,0.0004008012,0.0002180418,0.00893598],"study_design_scores_gemma":[0.00005169807,0.0009432501,0.001291749,0.00003538655,0.00006207916,0.0006712211,0.00004745479,0.002490764,0.9885036,0.0001709112,0.005710717,0.00002104481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8146496,0.03431455,0.1331707,0.001793924,0.0004786306,0.0004525345,0.0004055756,0.0009785929,0.01375568],"genre_scores_gemma":[0.9306919,0.01264005,0.04460736,0.0004406903,0.0001550966,0.0002365263,0.0001541866,0.000087232,0.01098693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002832701,"threshold_uncertainty_score":0.00563246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0741115189746451,"score_gpt":0.2847105430707936,"score_spread":0.2105990240961485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}