{"id":"W2082319347","doi":"10.1038/gt.2015.25","title":"Gene delivery to the spinal cord using MRI-guided focused ultrasound","year":2015,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":93,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Toronto Rehabilitation Institute; Sunnybrook Hospital; Sunnybrook Health Science Centre","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research","keywords":"Spinal cord; Gene delivery; Microbubbles; Genetic enhancement; Magnetic resonance imaging; Green fluorescent protein; Viral vector; Biology; Medicine; Pathology; Neuroscience; Ultrasound; Gene; Radiology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001580034,0.0001645413,0.0001385597,0.00004884441,0.0001268374,0.00006509462,0.0002931849,0.00005557628,0.00004049153],"category_scores_gemma":[0.000007681751,0.000125447,0.0000593878,0.0002516924,0.00002702524,0.00005979921,0.00001344637,0.00009568449,0.0001799924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000812986,"about_ca_system_score_gemma":0.00004630694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008461929,"about_ca_topic_score_gemma":0.00003120017,"domain_scores_codex":[0.9991903,0.00002480444,0.0001724384,0.000171675,0.0001695735,0.0002712368],"domain_scores_gemma":[0.9993059,0.00002730644,0.00002155833,0.0004298749,0.00007195186,0.0001434253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009927816,0.00003336576,0.0002401663,0.000003032827,0.00009788916,0.000002221807,0.0007051997,0.02945897,0.9341579,0.00006508734,0.004761422,0.03037545],"study_design_scores_gemma":[0.00268285,0.00070912,0.006441309,0.00002977344,0.00007857825,0.0003199863,0.0003939277,0.006715219,0.502329,0.001591706,0.477487,0.001221527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9761835,0.002424327,0.01984955,0.0002685972,0.0002773186,0.0003244625,0.00001565687,0.0002152123,0.0004414078],"genre_scores_gemma":[0.98874,0.0004575819,0.00936639,0.0006946825,0.0005441956,0.00005524665,0.000009802589,0.00005640741,0.00007569937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4727256,"threshold_uncertainty_score":0.5115579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0741115189746451,"score_gpt":0.2847105430707936,"score_spread":0.2105990240961485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}